METHOD FOR PREDICTING HOSPITAL-ACQUIRED INTESTINAL INFECTION IN INFANT

• 1. 用于测量医院获得性感染发病率的方法 [P] . 中国专利： CN106295127A . 2017-01-04
• 2. 用于测量医院获得性感染发病率的方法 [P] . 中国专利： CN101432740B . 2016.08.10
• 3. A method for predicting hospital infection CHILD infancy of intestinal infections [P] . 俄罗斯专利： RU2013147368A . 2015-04-27

  机译： 预测医院感染儿童肠道感染婴儿期的方法

• 4. METHOD OF TREATMENT Acute intestinal infections in infants [P] . 俄罗斯专利： RU2008105255A . 2009-08-20

  机译： 治疗方法婴儿急性肠感染

• 5. METHOD FOR PREDICTING CLINICAL COURSE OF ACUTE INTESTINAL INFECTIONS IN CHILDREN [P] . 俄罗斯专利： RU2275634C2 . 2006-04-27

  机译： 儿童急性肠感染的临床诊断方法

• 1. Intestinal protozoa and intestinal helminthic infections among schoolchildren in Central Sudan [J] . Abdel-aziz M Ahmed, Azam A Afifi, Elfatih M Malik, 亚太热带医药杂志（英文版） . 2010,第004期
• 2. Estimating sensitivity and specificity from positive predictive value, negative predictive value and prevalence: application to surveillance systems for hospital-acquired infections. [J] . Kelly H, Bull A, Russo P, The Journal of hospital infection . 2008,第2期
• 3. A mixed-methods study of hospital-acquired infections in Mongolia [J] . B-E Ider, A Clements, J Adams, BMC proceedings. . 2011,第S6期
• 4. Using the Electronic Health Record Data in Real Time and Predictive Analytics to Prevent Hospital-Acquired Postoperative/ Surgical Site Infections [J] . Thomas Falen, Alice M. Noblin, O. Lucia Russell, The health care manager . 2018,第1期
• 5. Faster and Active Surveillance of Hospital-Acquired Infections: A Model for Settings with High Sensitivity Predictors [C] . IEEE International Conference on BioInformatics and BioEngineering . 2009
• 6. An improved method for the isolation and characterization of rat intestinal intraepithelial lymphocytes and its application in a model of helminth infection (Trichinella spiralis). [D] . Kearsey, Joy Adele. 1997
• 7. Validity of bag urine culture for predicting urinary tract infections in febrile infants: a paired comparison of urine collection methods [O] . Geun-A Kim, Ja-Wook Koo 2015
• 8. A mixed-methods study of hospital-acquired infections in Mongolia [O] . B-E Ider, A Clements, J Adams, 2011

• 1. Dual-sugar tests of small intestinal permeability are poor predictors of bacterial infections and mortality in cirrhosis: a prospective study [J] . Anika Vogt ,Philipp A Reuken ,Sven Stengel . 世界胃肠病学杂志：英文版 . 2016,第11期
• 2. BACKGROUND： Vibrio vulnifi cus inside the body could activate the NF-!B signaling pathwayand initiate the inflammatory cascade. The lung is one of the earliest organs affected by sepsisassociated with acute lung injury. High mobility group protein B1 （HMGB1） is an important late-actingpro-infl ammatory cytokine involving in the pathophysiology of sepsis. It is also involved in the injuryprocess in the lung, liver and intestine. There has been no report on the involvement of HMGB1 inVibrio vulnifi cus sepsis-induced lung injury.METHODS： Sixty rats were randomly divided into a normal control group （group A, n=10） anda Vibrio vulnificus sepsis group （group B, n=50）. Sepsis was induced in the rats by subcutaneousinjection of Vibrio vulnificus （concentration 6×108 cfu/mL, volume 0.1 mL/100g）） into the left lowerlimbs. The rats in group B were sacrifi ced separately 1, 6, 12, 24, and 48 hours after the infection.Their lungs were stored as specimens, lung water content was measured, and lung pathology wasobserved under a light microscope. The expressions of the HMGB1 gene and protein in the lungswere detected by RT-PCR and Western blot. Data were analyzed with one-way analysis of variance（ANOVA） and the LSD method for pair-wise comparison between the two groups. P〈0.05 wasconsidered statistically signifi cant.RESULTS： Compared to group A （0.652±0.177）, HMGB1 mRNA expression in the lungs ofgroup B was signifi cantly higher at 0 hour （1.161±0.358, P=0.013）, 24 hours （1.679±0.235, P=0.000）,and 48 hours （1.258±0.274, P=0.004） （P〈0.05）, and peaked at 24 hours. Compared to group A（0.594±0.190）, HMGB1 protein expression at 6 hours （1.408±0.567, P=0.026） after infection wassignificantly increased （P〈0. 05）, and peaked at 24 hours （2.415±1.064, P=0.000） after infection.Compared to group A （0.699±0.054）, lung water content was significantly increased at 6 hours（0.759±0.030, P=0.001）,12 hours （0.767±0.023, P=0.000）, 24 hours （0.771±0.043, P=0.000） and 48hours （0.789±0.137, P=0.000） after infection （P〈0.05）. Compared to group A, pathological changesat 12 hours in group B indicate marked pulmonary vascular congestion, interstitial edema andinfl ammatory infi ltration. Alveolar cavity collapse and boundaries of the alveolar septum could not beclearly identifi ed.CONCLUSION： Vibrio vulnifi cus sepsis can lead to injury in rat lungs, and increased HMGB1expression in lung tissue may be one of the mechanisms for injury from Vibrio vulnifi cus sepsis. [J] . Qiao-meng Qiu ,Zhong-wang Li ,Lu-ming Tang . 世界急诊医学杂志(英文) . 2011,第4期
• 3. Infant intestinal Enterococcus faecalis down-regulates inflammatory responses in human intestinal cell lines [J] . Lydia Hui Mei Ng ,Wai Ling Chow ,Yuan Kun Lee . 世界胃肠病学杂志：英文版 . 2008,第7期
• 4. New approaches to increase intestinal length: Methods used for intestinal regeneration and bioengineering [J] . Ali Shirafkan ,Mauro Montalbano ,Joshua Mc Guire . 世界移植杂志 . 2016,第1期
• 5. 婴儿巨细胞病毒感染的临床特征、诊治方法及近期预后分析 [C] . 欧阳文献 ,唐莲 ,姜涛 . 中华医学会第十八次全国儿科学术会议 . 2013
• 6. 3月内婴儿先天性肠无神经节细胞症新的诊疗方法应用及疗效随访 [A] . 侯金凤 . 2014