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STRUCTURE OF BINDING COMPLEX OF POLO-LIKE KINASE-1 AND EMI2-DERIVED PEPTIDE AND METHOD FOR DEVELOPING INHIBITOR OF POLY-LIKE KINASE-1 USING SAME
STRUCTURE OF BINDING COMPLEX OF POLO-LIKE KINASE-1 AND EMI2-DERIVED PEPTIDE AND METHOD FOR DEVELOPING INHIBITOR OF POLY-LIKE KINASE-1 USING SAME
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机译:POLO样激酶1和EMI2衍生肽的结合复合物的结构以及用相同方法开发聚激酶1抑制剂的方法
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摘要
The present invention relates to a three-dimensional crystal structure of a complex bound with a polo-like kinase-1 and emi2-derived peptides and, more specifically, to a screening method for screening inhibitor of a polo-like kinase-1 by using the same and also for investigating binding structure of the emi2-derived peptides binding to the polo-like kinase-1. According to the present invention, the three-dimensional crystal structure shows structural characteristics on binding of the polo-like kinase-1 and the emi2-derived peptides, thereby being able to be useful for medicine for contraception by developing compounds specifically binding to the polo-like kinase-1 or by screening a competitive inhibitor for the emi2-derived peptides.;COPYRIGHT KIPO 2016
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