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首页> 外国专利> Liposome composed of dope, and DOTAP cardiolipin or its variants; use of said liposome for dosing the genetic material for Cell transfection in vitro or in vivo; lipoplexo for genetic vaccination comprising Said liposome.

Liposome composed of dope, and DOTAP cardiolipin or its variants; use of said liposome for dosing the genetic material for Cell transfection in vitro or in vivo; lipoplexo for genetic vaccination comprising Said liposome.

机译：由浓液和DOTAP心磷脂或其变体组成的脂质体;所述脂质体在体外或体内用于定量遗传物质用于细胞转染的用途;包含所述脂质体的用于遗传接种的脂复合物。

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摘要

The present invention relates to liposomes composed of DOPE and/or of a variant of DOPE bearing at least one ligand for targeting dendritic cells, of DOTAP and/or of a variant of DOTAP bearing at least one ligand for targeting dendritic cells and of cardiolipin and/or of a variant of cardiolipin bearing at least one ligand for targeting dendritic cells; and to the use thereof as a genetic material carrier for preparing lipoplexes. The lipoplexes according to the invention are advantageous because of the limited cytotoxicity thereof in vivo; they are therefore of particular interest for gene vaccination; in a form encapsulated in a biodegradable and nonimmunogenic cell such as an alginate gel, they are particularly suitable in particular for oral vaccination of aquatic animals.
机译：本发明涉及脂质体，其由DOPE和/或具有至少一种靶向树突状细胞的配体的DOPE的变体，DOTAP和/或具有至少一种用于靶向树突状细胞的配体的DOTAP的变体和心磷脂组成。 /或带有至少一种用于靶向树突细胞的配体的心磷脂变体;及其作为制备脂质复合物的遗传物质载体的用途。由于本发明的脂质复合物在体内的细胞毒性有限，因此是有利的。因此，它们对于基因疫苗特别感兴趣;它们以包封在可生物降解且非免疫原性的细胞如藻酸盐凝胶中的形式，特别适用于水生动物的口服疫苗接种。

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