For interstitial fluid extraction device , manufacturing method thereof , and methods of analysis of tissue fluid using the device

• 1. 组织液提取用器件、其制造方法以及采用该器件的组织液分析方法 [P] . 中国专利： CN103800040A . 2014-05-21
• 2. 组织液提取用器件、其制造方法以及采用该器件的组织液分析方法 [P] . 中国专利： CN101987024A . 2011-03-23
• 3. Recovery system fluid sample analyte BODY AND MONITORING IN IT, AND METHOD OF EXTRACTION DEVICE interstitial fluid [P] . 俄罗斯专利： RU2004117068A . 2005-11-20

  机译： 回收系统中的流体样品分析物的体内和监测，以及提取装置间质液的方法

• 4. Cuffed Fluid Line Extraction Device for Extraction of Tissue Ingrowth Cuffs and Fluid Lines from a Body and Associated Methods of Use [P] . 美国专利： US2015257785A1 . 2015-09-17

  机译： 用于从体内提取组织内生袖带和输液管的袖带式输液管提取装置及其使用方法

• 5. The manufacturing process of a device for analysis of fluid flow in the soil, device for analysis of fluid flow in the soil, method and system for analysis of fluid flow in the soil [P] . BR102013029155A2 . 2015-10-13

  机译： 用于分析土壤中的流体的设备的制造过程，用于分析土壤中的流体的设备，用于分析土壤中的流体的方法和系统

• 1. 3D printed microfluidic devices:a review focused on four fundamental manufacturing approaches and implications on the field of healthcare [J] . Viraj Mehta, Subha N.Rath 生物设计与制作(英文) . 2021,第002期
• 2. Numerical methods for the magneto-mechanical coupling analysis of in-vessel components in Tokamak devices [J] . Xudong Li, Shejuan Xie, Cuixiang Pei, 力学快报(英文版) . 2019,第003期
• 3. Microfluidic Devices: Simple 3D Printed Scaffold‐Removal Method for the Fabrication of Intricate Microfluidic Devices (Adv. Sci. 9/2015) [J] . Vittorio Saggiomo Advanced Science . 2015,第9期
• 4. Extended-Nanofluidics: Fundamental Technologies, Unique Liquid Properties, and Application in Chemical and Bio Analysis Methods and Devices [J] . Kazuma Mawatari, Yutaka Kazoe, Hisashi Shimizu, Analytical chemistry . 2014,第9期
• 5. A simple method for fabrication of microfluidic paper-based analytical devices and on-device fluid control with a portable corona generator [J] . Jiang Yan, Hao Zhenxia, He Qiaohong, RSC Advances . 2016,第4期
• 6. Diamond Microfluidic Devices manufactured with the replica method [C] . Anna Karczemska, Dariusz Witkowski, Victor Ralchenko, International Conference on Perspective Technologies and Methods in MEMS Design . 2009
• 7. Novel methods for micellar electrokinetic chromatography and preconcentration on traditional microfluidic devices and the fabrication and characterization of paper microfluidic devices. [D] . Hoeman, Kurt W. 2009
• 8. Microfluidic Devices: Simple 3D Printed Scaffold‐Removal Method for the Fabrication of Intricate Microfluidic Devices (Adv. Sci. 9/2015) [O] . Vittorio Saggiomo, Aldrik H. Velders 2015
• 9. Novel methods for micellar electro kinetic chromatography and preconcentration on traditional micro fluidic devices and the fabrication and characterization of paper micro fluidic [O] . Hoeman Kurt W. 100
• 10. Methods for Fluid Separations, and Devices Capable of Separating Fluids. [R] . TeGrotenhuis, W. E., Stenkamp, V. S. 2003

• 1. Dielectric Analysis of Response Time in Electrorheological Fluids Developed for Medical Devices [J] . Naullage I. Perera ,Manik Pavan Maheswaram ,Dhruthiman Mantheni . 美国分析化学（英文） . 2011,第2期
• 2. 3D printed microfluidic devices:a review focused on four fundamental manufacturing approaches and implications on the field of healthcare [J] . Viraj Mehta ,Subha N.Rath . 生物设计与制造 . 2021,第002期
• 3. BACKGROUND： Vibrio vulnifi cus inside the body could activate the NF-!B signaling pathwayand initiate the inflammatory cascade. The lung is one of the earliest organs affected by sepsisassociated with acute lung injury. High mobility group protein B1 （HMGB1） is an important late-actingpro-infl ammatory cytokine involving in the pathophysiology of sepsis. It is also involved in the injuryprocess in the lung, liver and intestine. There has been no report on the involvement of HMGB1 inVibrio vulnifi cus sepsis-induced lung injury.METHODS： Sixty rats were randomly divided into a normal control group （group A, n=10） anda Vibrio vulnificus sepsis group （group B, n=50）. Sepsis was induced in the rats by subcutaneousinjection of Vibrio vulnificus （concentration 6×108 cfu/mL, volume 0.1 mL/100g）） into the left lowerlimbs. The rats in group B were sacrifi ced separately 1, 6, 12, 24, and 48 hours after the infection.Their lungs were stored as specimens, lung water content was measured, and lung pathology wasobserved under a light microscope. The expressions of the HMGB1 gene and protein in the lungswere detected by RT-PCR and Western blot. Data were analyzed with one-way analysis of variance（ANOVA） and the LSD method for pair-wise comparison between the two groups. P〈0.05 wasconsidered statistically signifi cant.RESULTS： Compared to group A （0.652±0.177）, HMGB1 mRNA expression in the lungs ofgroup B was signifi cantly higher at 0 hour （1.161±0.358, P=0.013）, 24 hours （1.679±0.235, P=0.000）,and 48 hours （1.258±0.274, P=0.004） （P〈0.05）, and peaked at 24 hours. Compared to group A（0.594±0.190）, HMGB1 protein expression at 6 hours （1.408±0.567, P=0.026） after infection wassignificantly increased （P〈0. 05）, and peaked at 24 hours （2.415±1.064, P=0.000） after infection.Compared to group A （0.699±0.054）, lung water content was significantly increased at 6 hours（0.759±0.030, P=0.001）,12 hours （0.767±0.023, P=0.000）, 24 hours （0.771±0.043, P=0.000） and 48hours （0.789±0.137, P=0.000） after infection （P〈0.05）. Compared to group A, pathological changesat 12 hours in group B indicate marked pulmonary vascular congestion, interstitial edema andinfl ammatory infi ltration. Alveolar cavity collapse and boundaries of the alveolar septum could not beclearly identifi ed.CONCLUSION： Vibrio vulnifi cus sepsis can lead to injury in rat lungs, and increased HMGB1expression in lung tissue may be one of the mechanisms for injury from Vibrio vulnifi cus sepsis. [J] . Qiao-meng Qiu ,Zhong-wang Li ,Lu-ming Tang . 世界急诊医学杂志(英文) . 2011,第4期
• 4. 电动增强的紫外LED/手机成像纸基分析装置(PAD)用于荧光增白剂的定量分析方法研究 [C] . 宋以珍 ,张秀秀 ,方芳 . 第21届全国色谱学术报告会 . -1
• 5. 基于PDMS微流控芯片的组织液透皮抽取方法及系统研究 [A] . 于海霞 . 2011