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HEPATITIS VIRUS CULTURE SYSTEMS USING STEM CELL-DERIVED HUMAN HEPATOCYTE-LIKE CELLS AND THEIR METHODS OF USE
HEPATITIS VIRUS CULTURE SYSTEMS USING STEM CELL-DERIVED HUMAN HEPATOCYTE-LIKE CELLS AND THEIR METHODS OF USE
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机译:利用干细胞衍生的人类肝细胞样细胞的肝炎病毒培养系统及其使用方法
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摘要
The invention relates to the discovery that DHH derived from stem cells are permissive for infection by hepatitis viruses (HV), such as hepatitis A virus (HAV), hepatitis B virus (HBV), hepatitis C virus (HCV), hepatitis D virus (HDV) and hepatitis E virus (HEV). Included in the invention are HV-permissive DHHs and methods of making an HCV-permissive DHH derived from a stem cell. Also included is an HV culture system comprising at least one HV-permissive DHH. The HV- permissive DHH and HV culture system are useful for conducting HV life cycle analyses, diagnosing a subject as being infected with HV, genotyping and characterizing the HV of a subject infected with HV, detecting drug resistance of HV obtained from a subject infected with HV, screening for and identify modulators of HV infection, and monitoring the effect of a treatment of HV in a subject.
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