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Broad Spectrum Vaccine Against Typhoidal and Non-typhoidal Salmonella Disease

机译：抗伤寒和非伤寒沙门氏菌病的广谱疫苗

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摘要

The present invention is drawn to multivalent Salmonella enterica serovar conjugate vaccines comprising conjugates of S. Typhimurium, S. Enteritidis, S. Choleraesuis, S. Typhi, S. Paratyphi A and optionally S. Paratyphi B, wherein the conjugates comprise a hapten antigen and a carrier antigen, wherein at least one of the hapten antigens or carrier antigens is characteristic of the Salmonella enterica serovar. The present invention also provides Salmonella enterica serovar reagent strains to produce the multivalent conjugate vaccines and attenuated Salmonella enterica serovars for use as vaccines.

机译：本发明涉及包含 S缀合物的多价沙门氏菌血清型缀合物疫苗。伤寒沙门氏菌，肠炎沙门氏菌，霍乱沙门氏菌，伤寒沙门氏菌，副伤寒沙门氏菌 A和可选的 S。副伤寒B，其中所述缀合物包含半抗原和载体抗原，其中至少一种半抗原或载体抗原是肠沙门氏菌血清型的特征。本发明还提供了肠沙门氏菌血清型试剂菌株，以生产多价结合疫苗和减毒的肠沙门氏菌血清型用作疫苗。 展开▼

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公开/公告号US2013129776A1

专利类型

公开/公告日2013-05-23

原文格式PDF

申请/专利权人 UNIVERSITY OF MARYLAND BALTIMORE;
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申请/专利号US201213670153

发明设计人 MYRON M. LEVINE;JAMES E. GALEN;SHARON M. TENNANT;RAPHAEL SIMON;
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申请日2012-11-06

分类号A61K39/385;

国家 US

入库时间 2022-08-21 16:49:58

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