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Composition comprising nuclear-envelope and nuclear-lamina binding chimeras for modulating gene expression

机译：包含核包膜和核层结合嵌合体的用于调节基因表达的组合物

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摘要

The present invention is directed to nucleic acid target-specific chimeric proteins comprising a nuclear-envelope and/or nuclear-lamina binding domain and a DNA binding domain. These proteins, as well as the nucleic acids encoding those proteins, can be used in methods to repress or down-regulate expression of selected genes. The DNA binding domains are preferably from naturally-occurring zinc finger proteins (ZFPs) or artificial zinc finger proteins (AZPs). Molecular switch systems for gene regulation are also provided.

机译：本发明涉及核酸靶特异性嵌合蛋白，其包含核包膜和/或核层结合域和DNA结合域。这些蛋白质以及编码这些蛋白质的核酸可用于抑制或下调所选基因表达的方法中。 DNA结合结构域优选来自天然存在的锌指蛋白（ZFP）或人工锌指蛋白（AZP）。还提供了用于基因调节的分子开关系统。

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公开/公告号AU2008201951B2

专利类型
公开/公告日2011-06-02

原文格式PDF
申请/专利权人 SYNGENTA PARTICIPATIONS AG;
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申请/专利号AU20080201951
发明设计人 TAKASHI SERA;
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申请日2008-05-02
分类号C12N15/09;A61K35/76;A61K38;A61K48;A61P9;A61P25/30;A61P31/20;A61P35;C07K14;C07K14/47;C07K19;C12N1/15;C12N1/19;C12N1/21;C12N5/02;C12N5/10;C12N15/62;C12N15/63;C12N15/82;C12P21/02;
国家 AU
入库时间 2022-08-21 18:01:18

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