首页>
外国专利>
Methods employing a multi-time point IC50 assay for selecting time points for time dependent inhibition assays of a test compound
Methods employing a multi-time point IC50 assay for selecting time points for time dependent inhibition assays of a test compound
展开▼
机译：使用多时间点IC50分析为受试化合物的时间依赖性抑制分析选择时间点的方法
展开▼
页面导航
摘要
著录项
相似文献
摘要
The invention provides a method of evaluating metabolism-based drug interactions. The method involves selecting time points for the determination of the inactivation rate constant of a time-dependent enzyme inhibitor based on the results of a multi-time point IC50 test. Advantageously, with the subject invention, the determination and use of the multi-time point IC50 test provides an indication of the inactivation rate of a test compound and eliminates trial and error tests associated with the selection of appropriate assay conditions for the second assay conducted to determine the inactivation rate constant of the test compound.
展开▼
