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首页> 外国专利> Asn-Asp-Asp-Cys-Glu-Leu-Cys-Val-Asn-Val-Ala-Cys-Thr alone or in combination with peptides of Thr-Thr-Ser-Gln-Val-Arg-Pro-Arg-OH -Use of Gly-Cys-Leu-OH peptides as therapeutic agents

Asn-Asp-Asp-Cys-Glu-Leu-Cys-Val-Asn-Val-Ala-Cys-Thr alone or in combination with peptides of Thr-Thr-Ser-Gln-Val-Arg-Pro-Arg-OH -Use of Gly-Cys-Leu-OH peptides as therapeutic agents

机译：Asn-Asp-Asp-Cys-Glu-Leu-Cys-Val-Asn-Val-Ala-Cys-Thr单独或与Thr-Thr-Ser-Gln-Val-Arg-Pro-Arg-OH的肽结合使用- Gly-Cys-Leu-OH肽作为治疗剂的用途

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摘要

The present invention is directed to the use of the peptide compound Asn-Asp-Asp-Cys-Glu-Leu-Cys-Val-Asn-Val-Ala-Cys-Thr-Gly-Cys-Leu-OH or its combination with the peptide Thr-Thr-Ser-Gln-Val-Arg-Pro-Arg-OH as a therapeutic agent for the prophylaxis and/or treatment of cancer, autoimmune diseases, fibrotic diseases, inflammatory diseases, neurodegenerative diseases, infectious diseases, lung diseases, heart and vascular diseases and metabolic diseases. Moreover the present invention relates to pharmaceutical compositions preferably in form of a lyophilisate or liquid buffer solution or artificial mother milk formulation or mother milk substitute containing the peptide Asn-Asp-Asp-Cys-Glu-Leu-Cys-Val-Asn-Val-Ala-Cys-Thr-Gly-Cys-Leu-OH optionally together with at least one pharmaceutically acceptable carrier, cryoprotectant, lyoprotectant, excipient and/or diluent.
机译：本发明涉及肽化合物Asn-Asp-Asp-Cys-Glu-Leu-Cys-Val-Asn-Val-Ala-Cys-Thr-Gly-Cys-Leu-OH的用途或与它们的组合的用途。肽Thr-Thr-Ser-Gln-Val-Arg-Pro-Arg-OH作为预防和/或治疗癌症，自身免疫性疾病，纤维化疾病，炎性疾病，神经退行性疾病，传染病，肺病的治疗剂，心脏和血管疾病及代谢性疾病。此外，本发明涉及药物组合物，其优选为冻干物或液体缓冲溶液或人工母乳制剂或母乳替代物形式，其包含肽Asn-Asp-Asp-Cys-Glu-Leu-Cys-Val-Asn-Val- Ala-Cys-Thr-Gly-Cys-Leu-OH任选地与至少一种药学上可接受的载体，冷冻保护剂，冻干保护剂，赋形剂和/或稀释剂一起。

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