首页> 外国专利> FVIII protein and isolated nucleic acid molecule or modified isolated nucleic acid sequence encoding FVIII protein, isolated nucleic acid molecule, expression vector, host cell expressing FVIII protein, non-human transformed organism expressing FVIII protein, FVIII Composition comprising protein, method for producing FVIII protein, use of FVIII protein, method comprising administering FVIII protein in an amount effective for coagulation

FVIII protein and isolated nucleic acid molecule or modified isolated nucleic acid sequence encoding FVIII protein, isolated nucleic acid molecule, expression vector, host cell expressing FVIII protein, non-human transformed organism expressing FVIII protein, FVIII Composition comprising protein, method for producing FVIII protein, use of FVIII protein, method comprising administering FVIII protein in an amount effective for coagulation

机译：FVIII蛋白和编码FVIII蛋白的分离的核酸分子或修饰的分离的核酸序列，分离的核酸分子，表达载体，表达FVIII蛋白的宿主细胞，表达FVIII蛋白的非人类转化生物，包含该蛋白的FVIII组合物，生产FVIII蛋白的方法，FVIII蛋白的用途，方法包括以对凝血有效的量施用FVIII蛋白

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摘要

There is provided in accordance with the practice of this invention a demannosylated Factor VIII, the immunogenicity of which is substantially decreased or abolished in Human. The modified factor VIII is disclosed together with the modified amino acid sequence, changed by at least one substitution. The modified factor VIII is useful for hemophiliacs, either to avoid or prevent the action of inhibitory anti-idiotypic antibodies.

机译：根据本发明的实践，提供了去人糖基化的因子VIII，其在人中的免疫原性被大大降低或消除。公开了经修饰的因子VIII与经至少一个取代改变的经修饰的氨基酸序列。修饰的VIII因子可用于血友病患者，以避免或阻止抑制性抗独特型抗体的作用。

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公开/公告号JP2010524453A

专利类型
公开/公告日2010-07-22

原文格式PDF
申请/专利权人エルエフビーバイオテクノロジース;インスチチュートナショナルデラサンテエトデラルシェルシェメディケール;
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申请/专利号JP20100503618
发明设计人チョトウロウアブデスサタ;サミ;ラクロイクス－デスムゼスセバスチャン;カベリスリニバス;ダスグプタサーヤサラテ;バイリージャガデーシュ;
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申请日2008-04-21
分类号C12N15/09;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C07K14/755;C12P21/02;A61K38/43;A61P7/04;A61P43;
国家 JP
入库时间 2022-08-21 19:02:53

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