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AN IMPROVED PROCESS FOR THE PREPARATION OF NONSTEROIDAL ANTINFLAMMATORY DRUG

机译:非甾体类抗炎药的制备工艺的改进

摘要

etherifying benzoic of the formula (2) with succinic anhydride of the formula (3) in the presence of a hydrocarbon solvent at a temperature in the range of 100-140 °C to produce the hemisuccinate of the formula (4), the hemisuccinate of the formula (4) is then cicelies in an inert atmosphere with ammonia or an ammonia generating agent to produce Oxaprozin of the formula (1).
机译:在烃溶剂存在下,在100-140℃的温度下,将式(2)的苯甲酸与式(3)的琥珀酸酐醚化,以制备式(4)的半琥珀酸酯,即式(4)的半琥珀酸酯。然后将式(4)在惰性气氛中与氨或氨发生剂混合,以制备式(1)的奥沙普嗪。

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