首页> 外国专利> Methods for reducing the content of one or more contaminants, the protein content in a composition, the content of one or more protein contaminants in a cell culture supernatant, the protein content in a cell culture supernatant. , composition comprising a vitamin k-dependent protein of interest

Methods for reducing the content of one or more contaminants, the protein content in a composition, the content of one or more protein contaminants in a cell culture supernatant, the protein content in a cell culture supernatant. , composition comprising a vitamin k-dependent protein of interest

机译：减少一种或多种污染物含量，组合物中蛋白质含量，细胞培养上清液中一种或多种蛋白质污染物含量，细胞培养上清液中蛋白质含量的方法。，包含感兴趣的维生素K依赖性蛋白的组合物

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METHODS FOR REDUCING THE CONTENT OF ONE OR MORE CONTAMINANTS, THE CONTENT OF PROTEIN S IN A COMPOSITION, THE CONTENT OF ONE OR MORE PROTEIN CONTAMINANTS, THE PROTEIN 5 CONTENT IN A CULTURE CULTURE COMPOSITION UNDERSTANDING A VITAMIN K DEPENDENT PROTEIN OF INTEREST. The invention relates to vitamin K-dependent protein compositions having a very low or negligible protein contaminant content. The present invention also relates to a method applicable in the preparation of such vitamin K dependent protein compositions. Such methods may be used alone or in sequential combination for the purpose of reducing the relative content of protein contaminants. The present invention is especially relevant in the preparation of coagulation factor compositions chosen from factor X polypeptides (FX / FXa), factor IX polypeptides (FIX / FIXa), factor VII polypeptides (FVII / FVIIa) and anticoagulant protein C , especially factor VII polypeptides.

机译：降低一种或多种污染物含量，一种组合物中蛋白质S的含量，一种或多种蛋白质污染物中一种或多种维生素C含量相关的文化构成物中的蛋白质5含量的方法。本发明涉及具有非常低或可忽略的蛋白质污染物含量的维生素K依赖性蛋白质组合物。本发明还涉及可用于制备此类维生素K依赖性蛋白组合物的方法。为了减少蛋白质污染物的相对含量，这些方法可以单独使用或以顺序组合使用。本发明特别涉及制备选自因子X多肽（FX / FXa），因子IX多肽（FIX / FIXa），因子VII多肽（FVII / FVIIa）和抗凝血蛋白C，尤其是因子VII多肽的凝血因子组合物。。

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公开/公告号BRPI0519626A2

专利类型
公开/公告日2009-02-25

原文格式PDF
申请/专利权人 NOVO NORDISK HEALTH CARE AG;
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申请/专利号BR2005PI19626
发明设计人 ANNE CHARLOTTE ARENTSEN;DANIEL E. RASMUSSEN;ARE BOGSNES;ARNE STABY;HALEH AHMADIAN;SUSANNE BANG;JANUS KRARUP;THOMAS BUDDE HANSEN;
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申请日2005-12-23
分类号C07K1/16;C07K14/745;
国家 BR
入库时间 2022-08-21 19:28:31

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