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SYSTEMS AND METHODS FOR DELIVERING A RAPAMYCIN ANALOG THAT DO NOT INHIBIT HUMAN CORONARY ARTERY ENDOTHELIAL CELL MIGRATION
SYSTEMS AND METHODS FOR DELIVERING A RAPAMYCIN ANALOG THAT DO NOT INHIBIT HUMAN CORONARY ARTERY ENDOTHELIAL CELL MIGRATION
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机译:提供不抑制人冠状动脉内皮细胞迁移的雷帕霉素类似物的系统和方法
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摘要
A drug-eluting endoprosthesis is configured for inhibiting restenosis and thrombosis, and for promoting healing of a lesion in a body of a subject. Such an endoprosthesis includes at least a supporting structure and a therapeutically effective amount of the rapamycin analog is disposed thereon. The therapeutically effective amount of the rapamycin analog allows for the rapamycin analog to elute from the supporting structure so as to obtain a concentration of the rapamycin analog that is sufficient for inhibiting restenosis and/or inhibiting thrombosis. Also, the therapeutically effective amount of rapamycin analog is substantially devoid of inhibiting cell migration such that migrating cells promote healing of the lesion.
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