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Inhibition of growth and invasion of brain tumor cells by expression of AMPA-type glutamate receptor subunit
Inhibition of growth and invasion of brain tumor cells by expression of AMPA-type glutamate receptor subunit
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机译:AMPA型谷氨酸受体亚基的表达抑制脑肿瘤细胞的生长和侵袭
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摘要
The present invention is to provide a method of treatment which inhibits proliferation and invasion of brain tumor cells in developing animal brain tumor cells, and a method for measuring proliferation/invasion activity of brain tumor cells, in the brain tumor cells, preferably, in glioblastoma. Proliferation and invasion of brain tumor cells are inhibited by regulating Ca2+ permeability by glutamate receptor subunits in developing animal brain tumor cells. Regulation of Ca2+ permeability by glutamate receptor subunits can be conducted by introducing the GluR2 gene into AMPA-type glutamate receptors in brain tumor cells. Further, the present invention provides a method for measuring proliferation/invasion activity of brain tumor cells by detecting/measuring the expression of glutamate receptor subunits in developing animal brain tumor cells. IMAGE
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