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Vaccines of bacterial outer membrane vesicles

机译：细菌外膜囊泡疫苗

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摘要

The present invention relates to an immuno-protective and non-toxic Gram-negative bleb vaccine suitable for paediatric use. Examples of the Gram-negative strains from which the blebs are made are N. meningitidis, M. catarrhalis and H. influenzae. The blebs of the invention are improved by one or more genetic changes to the chromosome of the bacterium, including up-regulation of protective antigens, down-regulation of immunodominant non-protective antigens, and detoxification of the Lipid A moiety of LPS.

机译：本发明涉及适用于儿科用途的免疫保护和无毒的革兰氏阴性起泡疫苗。产生气泡的革兰氏阴性菌株的例子是N。脑膜炎，粘膜炎莫拉氏菌和 H。通过对细菌染色体的一种或多种遗传改变，包括保护性抗原的上调，免疫性非保护性抗原的下调和脂质A的解毒，可以改善本发明的气泡。 LPS的部分。 展开▼

著录项

公开/公告号EP1792994A3

专利类型

公开/公告日2007-10-10

原文格式PDF

申请/专利权人 GLAXOSMITHKLINE BIOLOGICALS S.A.;
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申请/专利号EP20060124090

发明设计人 BERTHET FRANCOIS-XAVIER J.SMITHKLINE BEECHAM;DALEMANS WILFRIED L.SMITHKLINE BEECHAM;DENOEL PHILIPPESMITHKLINE BEECHAM;DEQUESNE GUYSMITHKLINE BEECHAM;FERON CHRISTIANESMITHKLINE BEECHAM;LOBET YVESSMITHKLINE BEECHAM;POOLMAN JANSMITHKLINE BEECHAM;THIRY GEORGESSMITHKLINE BEECHAM;THONNARD JOELLESMITHKLINE BEECHAM;VOET PIERRESMITHKLINE BEECHAM;
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申请日2000-07-31

分类号C12N15/74;A61K39/02;C12N15/31;C12N15/67;A61K39/095;A61K39/116;A61K39/118;A61K39/09;A61K39/104;A61K39/102;A61K39/295;C07K14/195;C12N1/21;

国家 EP

入库时间 2022-08-21 20:43:28

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1. 一种细菌外膜囊泡、包含该细菌外膜囊泡的通用纳米疫苗及其制备方法和应用 [P] . 中国专利： CN112472802A . 2021-03-12

2. 一种载药细菌外膜囊泡及其制备方法和应用 [P] . 中国专利： CN110478331B . 2022.02.18

3. Process for the high-level expression of the outer membrane protein P2 of haemophilus influenzae type B (HIB-P2) in E.coli; purification process of the outer membrane protein P2 or fusion protein thereof, reduplication process of the outer membrane protein P2 or fusion protein obtained; substantially pure reduplicated P2 outer membrane protein from haemophilus influenzae type B (HIB-P2) or fusion protein thereof; vaccine comprising the outer membrane protein P2 of hamophilus influenzae type B (HIB-P2) or a fusion protein thereof; process for obtaining a P2 protein or P2-polysaccharide fusion protein conjugate; process to prevent bacterial meningitis in an animal; pNV-3 vector; pNV-2 vector, and pNV-6 vector [P] . BR9407144A . 1996-09-17

机译：乙型流感嗜血杆菌外膜蛋白P2（HIB-P2）在大肠杆菌中高水平表达的方法;外膜蛋白P2或其融合蛋白的纯化过程，外膜蛋白P2或其融合蛋白的重复过程;来自B型流感嗜血杆菌的基本上纯的复制的P2外膜蛋白（HIB-P2）或其融合蛋白;疫苗，其包含B型流感嗜血杆菌的外膜蛋白P2（HIB-P2）或其融合蛋白;获得P2蛋白或P2-多糖融合蛋白缀合物的方法;预防动物细菌性脑膜炎的过程; pNV-3载体; pNV-2矢量和pNV-6矢量

4. Method of antigen incorporation into neisseria bacterial outer membrane vesicles and resulting vaccine formulations [P] . NZ547519A . 2009-01-31

机译：将抗原掺入奈瑟菌细菌外膜囊泡中的方法和所得疫苗制剂

5. Vaccines of bacterial outer membrane vesicles [P] . 欧洲知识产权局专利： EP1792994A2 . 2007-06-06

机译：细菌外膜囊泡疫苗

1. CAS Structural Biologists Detail How Lipopolysaccharides Transport and Insert in Gram-Negative Bacterial Outer Membrane [J] . 中国科学院院刊（英文版） . 2014,第004期

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3. The Characterization of Novel Transgenic Murine Models of Neisseria gonorrhoeae Infection and Development of a Natural Outer Membrane Vesicle Anti-Gonococcal Vaccine Candidate [D] . Francis, Ian P. 2020

4. Exploiting bacterial outer membrane vesicles as a cross-protective vaccine candidate against avian pathogenic Escherichia coli (APEC) [O] . Rujiu Hu, Jing Li, Yuezhen Zhao, 2020

5. Bioengineering bacterial outer membrane vesicles as vaccine platform [O] . Matthias J.H. Gerritzen, Dirk E. Martens, René H. Wijffels, 2017

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