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Vaccines for the rapid response to pandemic avian influenza

机译:快速应对大流行性禽流感的疫苗

摘要

The present invention relates to adenovirus-based vaccines against avian influenza viruses with pandemic potential. The present invention provides replication-defective adenoviral vectors, each having a nucleic acid encoding an influenza A polypeptide. When introduced into a subject, the expressed influenza A polypeptide induces the production of antibodies that bind to influenza. The present invention also provides methods for inducing an immune response in a subject. Subjects are administered a replication-defective adenoviral vector, wherein the vector has a nucleic acid encoding an influenza A polypeptide. When the vector is expressed in the subject, the influenza A polypeptide induces the subject to produce antibodies to influenza.
机译:本发明涉及针对具有大流行潜力的禽流感病毒的基于腺病毒的疫苗。本发明提供了复制缺陷型腺病毒载体,每个载体均具有编码甲型流感多肽的核酸。当引入受试者时,表达的甲型流感多肽诱导结合流感的抗体的产生。本发明还提供了在受试者中诱导免疫应答的方法。给受试者施用复制缺陷型腺病毒载体,其中该载体具有编码甲型流感多肽的核酸。当载体在受试者中表达时,A型流感多肽诱导受试者产生针对流感的抗体。

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