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Recombinant antigen MSP1a from anaplasma marginale to reduce infections in ticks, vaccine compositions and methods of use

机译：来自无缘种的重组抗原MSP1a，以减少tick感染，疫苗组合物和使用方法

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摘要

Vaccines and methods for inducing an immune response in a ruminant. The vaccine composition including pathogen and tick-derived antigens and a carrier or diluent. The method for inducing an immune response in a ruminate to provide immune protection which reduces the infection of ticks by A. marginale and/or prevents the transmission of the pathogen includes the steps of administering to the ruminant an effective amount of the vaccine composition having at least one antigen member of the group comprising at least one antigen member of the group comprising (i) recombinant MSP1a surface protein antigen of A. marginale, (ii) a subunit of recombinant MSP1a surface protein antigen of A. marginale and (iii) recombinant MSP1a surface protein antigen or subunits thereof in combination with antigen preparation derived from A. marginale infected cultured tick IDE8 cells and/or other pathogen and tick-derived antigens, and a carrier or diluent.

机译：在反刍动物中诱导免疫反应的疫苗和方法。疫苗组合物包括病原体和壁虱来源的抗原以及载体或稀释剂。用于在反刍动物中诱导免疫应答以提供免疫保护的方法，该免疫保护减少了A对infection的感染。边缘和/或防止病原体的传播包括对反刍动物施用有效量的疫苗组合物的步骤，所述疫苗组合物具有所述组的至少一种抗原成员，所述组包括以下至少一种抗原成员：）的重组MSP1a表面蛋白抗原。（ii） A的重组MSP1a表面蛋白抗原的亚基。和（iii）重组MSP1a表面蛋白抗原或其亚基，以及与 A衍生的抗原制剂结合使用。感染了边缘的受感染的壁虱IDE8细胞和/或其他病原体和壁虱衍生的抗原，以及载体或稀释剂。 展开▼

著录项

公开/公告号US6979451B1

专利类型

公开/公告日2005-12-27

原文格式PDF

申请/专利权人 JOSE DE JESUS DE LA FUENTE;KATHERINE M. KOCAN;JOSE CARLOS GARCIA-GARCIA;EDMOUR F. BLOUIN;
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申请/专利号US20020285319

发明设计人 JOSE DE JESUS DE LA FUENTE;KATHERINE M. KOCAN;JOSE CARLOS GARCIA-GARCIA;EDMOUR F. BLOUIN;
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申请日2002-10-31

分类号A61K39/00;A61K39/002;A61K39/38;A01N63/00;A01N65/00;

国家 US

入库时间 2022-08-21 21:40:57

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