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cDNAs and proteins involved in hypoxia, circadian and orphan signal transduction pathways, and methods of use

机译：涉及缺氧，昼夜节律和孤儿信号转导途径的cDNA和蛋白质及其使用方法

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摘要

The present invention provides isolated nucleic acids and proteins that are new and distinct members of the bHLH-PAS superfamily of transcription regulators. These “MOPs” (members of PAS) are useful in a variety of research, diagnostic and therapeutic applications. Several of the MOPs of the present invention are α-class hypoxia-inducible factors. Several other of the MOPs of the invention are involved in circadian signal transduction.

机译：本发明提供了分离的核酸和蛋白质，它们是转录调节子的bHLH-PAS超家族的新的和独特的成员。这些“ MOP”（PAS的成员）可用于各种研究，诊断和治疗应用。本发明的几种MOP是α类缺氧诱导因子。本发明的其他几个MOP涉及昼夜节律信号转导。

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公开/公告号US7105647B1

专利类型
公开/公告日2006-09-12

原文格式PDF
申请/专利权人 CHRISTOPHER A. BRADFIELD;YI ZHONG GU;JOHN B. HOGENESCH;
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申请/专利号US20000555362
发明设计人 YI ZHONG GU;JOHN B. HOGENESCH;CHRISTOPHER A. BRADFIELD;
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申请日1998-11-27
分类号C07H21/02;
国家 US
入库时间 2022-08-21 21:44:39

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