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men1, multiple endocrine neoplasia associated with type 1 gene, meninpolypeptide and their uses

机译：men1，与1型基因相关的多发性内分泌肿瘤，menin多肽及其用途

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摘要

This invention relates to the discovery of a novel tumor suppressor gene which is associated with multiple endocrine neoplasia type 1. The gene has been designated MEN1 and the gene product is menin. The absence of this protein and associated mutations in the corresponding gene have been identified in individuals suffering from multiple endocrine neoplasia type 1. The identification of this marker for multiple endocrine neoplasia type 1 has diagnostic uses as well as for gene therapy.

机译：本发明涉及与多发性内分泌肿瘤1型有关的新型肿瘤抑制基因的发现。该基因被命名为MEN1，基因产物是menin。在患有多发性内分泌肿瘤1型的个体中已经鉴定出该蛋白质的缺失和相关基因中的相关突变。针对多发性内分泌肿瘤1型的该标志物的鉴定具有诊断用途以及用于基因治疗。

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公开/公告号DE69828986D1

专利类型
公开/公告日2005-03-17

原文格式PDF
申请/专利权人 THE GOVERNMENT OF THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES BETHESDA;
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申请/专利号DE19986028986T
发明设计人 CHANDRASEKHARAPPA SETTARA C.;GURU C.;MANICKAM PACHIAPPAN;COLLINS S.;EMMERT-BUCK R.;DEBELENKO V.;LUBENSKY A.;LIOTTA A.;AGARWAL K.;SPIEGEL M.;BURNS LEE;MARX J.;
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申请日1998-03-04
分类号C12N15/12;C07K14/47;G01N33/574;C12Q1/68;A61K48/00;C12N15/86;C07K16/18;A01K67/027;
国家 DE
入库时间 2022-08-21 21:58:56

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