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Kinship analysis program for missing persons and mass disaster
Kinship analysis program for missing persons and mass disaster
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机译：失踪人员和大规模灾难的亲属关系分析程序
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摘要
A kinship analysis program for missing persons and mass disasters for kinship and missing persons analyses. The inventive device includes consensusG, Kinship Indices, Matching, cross-checking, pedigree that performs the following: Extract a list of unique victims' genotypes from the remains or missing persons database, make perfect matches to personal effect, identify next-of-kin related to a victim, make matches through parentage trios, confirm consistency of family pedigrees, exclude nearly all fortuitous hits on the basis of the SM scoring performance of the entire family of the relative that triggered the fortuitous hit, make matches despite the known existence of errors in sample names and reported relationships, flag samples with inconsistent reported relationships, display matches in their context, so that “close-calls” are brought to the attention of the data reviewer. An algorithm which reduces very large collections of complete/partial STR (Short Tandem Repeats) genotypes derived from the remains down to a restricted number of consensus genotypes believed to reflect the many different victims. An algorithm which calculates Kinship Indices through a segregated score approach and likelihood ratio calculations through a linkage to the KinTest software. An algorithm which contrasts the consensus genotypes against the data set of genotypes from next-of-kin and personal effects for direct matches to personal effects, for evidence of genetic relatedness to kin through the Kinship Indices, or for successful production of a parentage trio with any two members of the next-of-kin cohort. An algorithm which cross-checks matches to parentage trios against other kinship scoring results between the victim and other members of the same family to confirm that the purported family structure is consistent with Mendelian inheritance rules. A schematic diagram describing the relationship of the relatives to a matched victim. A user interface that is accessible to a broader range of users.
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