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Regulation of JNK activity by modulation of the interaction between the endocytic protein endophilin and the germinal center kinase-like kinase
Regulation of JNK activity by modulation of the interaction between the endocytic protein endophilin and the germinal center kinase-like kinase
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机译：通过调节内吞蛋白endophilin和生发中心激酶样激酶之间的相互作用来调节JNK活性
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摘要
Endophilin I is a brain-specific protein functioning in clathrin-mediated endocytosis. The present invention is based on the finding that the rat germinal center kinase-like kinase (rGLK), a member of the germinal center kinase (GCK) family of c-jun N-terminal kinase (JNK) activating enzymes, is a novel endophilin I-binding partner. In a first aspect of the present invention, the novel interaction between endophilin I and rGLK is put to use in a novel screening assay. In a second aspect of the present invention, the interaction between endophilin I and GLK is modulated for therapeutic purposes, namely for the prevention and/or curtailment of neurological disorders associated with the JNK pathway. JNK-mediated neuronal cell death is believed to play an important role in injuries and diseases involving neuronal degeneration, such as Huntington's disease.
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