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Recombinant production of a soluble splice variant of the Fas (Apo-1) antigen, fas TM

机译:Fas(Apo-1)抗原fas TM的可溶性剪接变体的重组产生

摘要

The invention provides soluble forms of the Fas (Apo-1 ) protein comprising both the intracellular and extracellular domains of the full- length polypeptide. Exemplified is a naturally-occurring splice variant of the Fas gene, FasTM, which lacks the transmembrane domain of the native antigen. DNA encoding the protein, cells expressing the recombinant DNA, and methods of using the protein and DNA are also provided.
机译:本发明提供了包含全长多肽的细胞内和细胞外结构域的Fas(Apo-1)蛋白的可溶形式。举例来说,是Fas基因FasTM的天然剪接变体,该变体缺少天然抗原的跨膜结构域。还提供了编码蛋白质的DNA,表达重组DNA的细胞以及使用该蛋白质和DNA的方法。

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