首页> 外国专利> RECOMBINANT PROTEINS OF A PAKISTANI STRAIN OF HEPARECOMBINANT PROTEINS OF A PAKISTANI STRAIN OF HEPATITIS E AND THEIR USE IN DIAGNOSTIC METHODS AND VATITIS E AND THEIR USE IN DIAGNOSTIC METHODS AND VACCINES CCINES

RECOMBINANT PROTEINS OF A PAKISTANI STRAIN OF HEPARECOMBINANT PROTEINS OF A PAKISTANI STRAIN OF HEPATITIS E AND THEIR USE IN DIAGNOSTIC METHODS AND VATITIS E AND THEIR USE IN DIAGNOSTIC METHODS AND VACCINES CCINES

机译：帕金森氏菌肝炎肝炎蛋白的重组蛋白及其在诊断方法和疫苗中的用途及其在诊断方法和疫苗疫苗中的用途

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摘要

A strain of hepatitis E virus from Pakistan (SAR-55) implicated in an epidemic of enterically transmitted non-A, non-B hepatitis, now called hepatitis E, is disclosed. The invention relates to the expression of the whole structural region of SAR-55, designated open reading frame 2 (ORF-2), in a eukaryotic expression system. The expressed protein is capable of forming HEV virus-like particles which can serve as an antigen in diagnostic immunoassays and as an immunogen or vaccine to protect against infection by hepatitis E.

机译：公开了一种来自巴基斯坦的戊型肝炎病毒（SAR-55），与一种肠道传播的非甲非乙型肝炎流行有关，现在被称为戊型肝炎。本发明涉及在真核表达系统中SAR-55的整个结构区的表达，称为开放阅读框2（ORF-2）。表达的蛋白质能够形成HEV病毒样颗粒，可在诊断性免疫分析中用作抗原，并可作为免疫原或疫苗来预防戊型肝炎感染。

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公开/公告号WO9610580A3

专利类型
公开/公告日1996-05-23

原文格式PDF
申请/专利权人 THE GOVERNMENT OF THE UNITED STATES OF AMERICA RE;TSAREV SERGEI A.;EMERSON SUZANNE U.;PURCELL ROBERT H.;
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申请/专利号WO1995US13102
发明设计人 TSAREV SERGEI A.;EMERSON SUZANNE U.;PURCELL ROBERT H.;
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申请日1995-10-03
分类号C07K14/08;C12N15/51;A61K39/29;G01N33/576;C12Q1/70;
国家 WO
入库时间 2022-08-22 03:49:00

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