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Sieve Low Substitution Hydroxypropyl Cellulose Production Method

机译:筛床低替代羟丙基纤维素生产方法

摘要

PROBLEM TO BE SOLVED: To provide a method for producing a sieved L-HPC having an improved yield while maintaining the fluidity of hydroxypropyl cellulose (L-HPC) having a low degree of sieving and the tablet characteristics after tableting. SOLUTION: L-HPC having a hydroxypropoxy group content of 5 to 16% by mass is sieved using a sieve shaker in which the sieve surface moves horizontally to obtain a first residual L-HPC on the sieve. , The first sieving step of obtaining the first sieve-passing L-HPC and the second sieving of the residual L-HPC on the first sieve using a sieve shaker in which the sieving surface moves vertically. The second sieving step of obtaining the residual L-HPC on the sieve and the second L-HPC passing through the sieve, and the sieving L by combining the L-HPC passing through the first sieve and the residual L-HPC on the second sieve. Provided is a method for producing a sieved L-HPC, which comprises at least a mixing step for obtaining −HPC. [Selection diagram] None
机译:要解决的问题:提供一种制备筛分L-HPC的方法,其具有改善的产率,同时保持羟丙基纤维素(L-HPC)的流动性具有低筛分和压片后的片剂特性。溶液:使用筛振荡器筛分具有5至16质量%的羟丙氧基含量为5-16质量%的L-HPC,其中筛表面水平移动以在筛子上获得第一个残留的L-HPC。 ,使用筛振荡器在第一筛子上获得第一筛网通过L-HPC的第一筛分步骤和第二筛分的第二筛分,其中筛分表面垂直移动。通过将通过第一筛网和残留的L-HPC组合在第二筛子上将L-HPC与筛子和通过筛网的第二L-HPC获得残留L-HPC的第二筛分步骤和通过筛的第二L-HPC和筛分L. 。提供了一种制备筛分L-HPC的方法,其至少包含用于获得-HPC的混合步骤。 [选择图]无

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