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Combination therapy with targeted TGF-β inhibition for the treatment of advanced non-small cell lung cancer

机译:针对靶向TGF-β抑制治疗晚期非小细胞肺癌的联合治疗

摘要

The present disclosure relates generally to a method of treating a subject diagnosed with advanced non-small cell lung cancer (NSCLC) involving targeted TGF-β inhibition with a bifunctional fusion protein, in combination with administration of a systemic chemotherapeutic agent. , Wherein the combination of the bifunctional fusion protein of the present disclosure and a systemic chemotherapeutic agent enhances anticancer efficacy compared to systemic chemotherapeutic agents alone.
机译:本公开一般涉及治疗诊断患有先进的非小细胞肺癌(NSCLC)的受试者的方法,涉及靶向TGF-β抑制与双官能融合蛋白的抑制,与给药的施用全身化学治疗剂。当单独的单独的全身化学治疗剂相比,本发明的双官能融合蛋白和全身化学治疗剂的组合增强了抗癌效果。

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