首页> 外国专利> SENSITIZING COMPOSITION USING ELECTROMAGNETIC WAVES FOR THERMAL THERAPY OF CANCERS, AND CANCER THERAPY USING SAME

SENSITIZING COMPOSITION USING ELECTROMAGNETIC WAVES FOR THERMAL THERAPY OF CANCERS, AND CANCER THERAPY USING SAME

机译:敏化组合物使用电磁波进行癌症热疗的热疗,以及使用该癌症治疗

摘要

Disclosed are a sensitizing composition for thermal cancer therapy using electromagnetic waves and a method of treating cancer using the composition. The sensitizing composition includes a metal ion, a metal ion-bound material, “metal ion-noncovalently bound apotransferrin” (transferrin), or a metal ion-noncovalently bound apotransferrin derivative. The sensitizing composition enables selective delivery of the metal ion to tumorous tissue when administered in vivo, and thus the generation of heat in tumorous tissue in which the metal ion accumulates is increased upon thermal cancer therapy using electromagnetic waves, thereby maximizing efficacy of thermal cancer therapy using electromagnetic waves in treating cancer. Thermal therapy using the sensitizing composition effectively treats cancer without pain or side effects and is thus expected to be widely useful in anticancer treatment as monotherapy, and/or in combination with chemotherapy, radiation therapy, or a combination thereof, ultimately increases the potential to cure cancer.
机译:公开了一种用于使用电磁波的热癌治疗的敏化组合物和使用该组合物治疗癌症的方法。敏化组合物包括金属离子,金属离子结合材料,“金属离子 - 非共价结合的肺转移素”(转移素),或金属离子离子 - 非共价结合的鼻转毒素衍生物。当体内给药时,敏化组合物能够选择性地将金属离子与肿瘤组织一起递送到肿瘤组织中,从而在使用电磁波热癌症治疗时增加金属离子累积的肿瘤组织中的热量,从而最大化热癌治疗的功效使用电磁波治疗癌症。使用敏化组合物的热疗法有效地治疗癌症而不疼痛或副作用,因此预期在抗癌治疗中被广泛可用于单一疗法,和/或与化疗,放射治疗或其组合组合,最终增加了治愈的潜力癌症。

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