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MCF-7 MCF-7 cell line having anticancer drug resistance and method for preparing same

机译:MCF-7 MCF-7细胞系具有抗癌耐药性和制备方法

摘要

To an MCF-7 cell line having anticancer drug resistance and a method for preparing the same, the method comprising: administering a CDK4/6 inhibitor to a mouse transplanted with the MCF-7 cell line; and separating resistant cells that have acquired resistance to the CDK4/6 inhibitor from the tumor tissue of the MCF-7 cell line transplanted mouse administered with the CDK4/6 inhibitor; a method for producing a CDK4/6 inhibitor-resistant cell line comprising a; , It provides a composition for screening a cancer therapeutic agent comprising a CDK4/6 inhibitor-resistant cell line prepared by the above method, and a screening method.
机译:对于具有抗癌耐药性的MCF-7细胞系及其制备方法,该方法包括:将CDK4 / 6抑制剂施用与MCF-7细胞系移植的小鼠; 并将对CDK4 / 6抑制剂的抗性从MCF-7细胞系移植的小鼠的肿瘤组织中获得抗性细胞,与CDK4 / 6抑制剂给药的肿瘤组织; 一种制备包含a的CDK4 / 6抑制剂抗细胞系的方法; ,它提供了一种用于筛选包含通过上述方法制备的CDK4 / 6抑制剂抗性细胞系的癌症治疗剂的组合物和筛选方法。

著录项

  • 公开/公告号KR20210120715A

    专利类型

  • 公开/公告日2021-10-07

    原文格式PDF

  • 申请/专利权人 차의과학대학교 산학협력단;

    申请/专利号KR20200037791

  • 发明设计人 문용화;박나희;판디 카말;

    申请日2020-03-27

  • 分类号C12N5/09;C12N15/85;C12Q1/6886;G01N33/50;

  • 国家 KR

  • 入库时间 2022-08-24 21:32:59

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