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Compositions and methods related to antibodies that neutralize coagulase activity during Staphylococcus aureus disease

机译：与抗体有关的组合物和方法，其在金黄色葡萄球菌疾病中中和凝固酶活性

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摘要

Embodiments concern methods and compositions for treating or preventing a bacterial infection, particularly infection by a Staphylococcus bacterium. Aspects include methods and compositions for providing a passive immune response against the bacteria. In certain embodiments, the methods and compositions involve an antibody that binds Coagulase (Coa). Further aspects relate to immunogenic compositions comprising at least one Staphylococcal coagulase R Domain, wherein the R Domain is 80% identical in sequence to a R Domain.

机译：实施方案涉及用于治疗或预防细菌感染的方法和组合物，特别是葡萄球菌细菌感染。方面包括用于为细菌提供被动免疫应答的方法和组合物。在某些实施方案中，方法和组合物涉及结合凝血酶（COA）的抗体。另一方面涉及包含至少一种葡萄球菌凝固素R结构域的免疫原性组合物，其中R结构域以序列与R结构域相同。

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公开/公告号US11214600B2

专利类型
公开/公告日2022-01-04

原文格式PDF
申请/专利权人 THE UNIVERSITY OF CHICAGO;JANSSEN PHARMACEUTICALS INC.;
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申请/专利号US201716077213
发明设计人 DOMINIQUE MISSIAKAS;OLAF SCHNEEWIND;CARLA EMOLO;LENA THOMER;MOLLY MCADOW;JEROEN GEURTSEN;MARK DE BEEN;
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申请日2017-02-10
分类号A61K39/02;A61K39;A61K45;A61K47;A61K39/085;A61K38;C07K2;C07K4;C07K5;C07K7;C07K14;C07K16;C07K17;C07K14/31;C07K16/12;C07K16/40;C12Q1/689;A61K39/40;
国家 US
入库时间 2022-08-24 23:11:23

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