首页> 外国专利> CANCER CELL DIAGNOSIS METHOD BASED ON SCAN CANTILEVER METHOD, DEVICE FOR ANALYZING DISTRIBUTION OF ELASTICITY CHARACTERISTICS OF SUBJECT CELLS, AND PROGRAM FOR CAUSING COMPUTER TO EXECUTE ANALYSIS OF DISTRIBUTION OF ELASTICITY CHARACTERISTICS OF SUBJECT CELLS

CANCER CELL DIAGNOSIS METHOD BASED ON SCAN CANTILEVER METHOD, DEVICE FOR ANALYZING DISTRIBUTION OF ELASTICITY CHARACTERISTICS OF SUBJECT CELLS, AND PROGRAM FOR CAUSING COMPUTER TO EXECUTE ANALYSIS OF DISTRIBUTION OF ELASTICITY CHARACTERISTICS OF SUBJECT CELLS

机译：基于扫描悬臂法的癌细胞诊断方法，分析受试细胞弹性特征分布的装置，以及使计算机执行受试细胞弹性特征分布分析的程序

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摘要

The present invention includes: a step in which an actual measurement value, that is obtained when a probe (24) of an atomic force microscope is pressed against a surface of a subject cell (3) and that associates a cell deformation quantity and a pressing force of the probe (24), is acquired together with measurement position coordinates of the subject cell (3) contacted by the probe (24), the measurement position coordinates of the subject cell (3) being disposed on a scan line so as to include an upper layer of a nucleus of the subject cell (3) and an area around the nucleus. The present invention also includes: a step in which, using a shape parameter determined in accordance with the shape of the tip of the probe (24) and a model formula that represents a relationship between the cell deformation quantity (d) and the pressing force (F) of the probe (24), a stress distribution of the subject cell (3) is computed; and a step in which a determination is made as to whether the stress distribution of the subject cell (3) calculated using the shape parameter is in a range within which the subject cell (3) is determined to be a normal cell.

机译：本发明包括：获取当原子力显微镜的探针（24）压在被摄体细胞（3）的表面上时获得的、与细胞变形量和探针（24）的压力相关联的实际测量值以及探针（24）接触的被摄体细胞（3）的测量位置坐标的步骤，被摄体细胞（3）的测量位置坐标设置在扫描线上，以便包括被摄体细胞（3）的细胞核的上层和细胞核周围的区域。本发明还包括：使用根据探针（24）尖端的形状确定的形状参数和表示探针（24）的单元变形量（d）和压力（F）之间关系的模型公式，计算目标单元（3）的应力分布的步骤；以及确定使用形状参数计算的对象单元（3）的应力分布是否在确定对象单元（3）为正常单元的范围内的步骤。

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公开/公告号WO2022054731A1

专利类型
公开/公告日2022-03-17

原文格式PDF
申请/专利权人 NATIONAL INSTITUTE FOR MATERIALS SCIENCE;UNIVERSITY OF TSUKUBA;
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申请/专利号WO2021JP32555
发明设计人 ZHANG HAN;WANG HONGXIN;DA BO;FUJITA DAISUKE;HANAGATA NOBUTAKA;ISHIDA NOBUYUKI;NOGUCHI MASAYUKI;KANO JUNKO;
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申请日2021-09-03
分类号G01N3/40;G01Q80;
国家 JP
入库时间 2022-08-25 00:00:05

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