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首页> 外文会议>2010 Proceedings 60th Electronic Components and Technology Conference >Assembly of a polymer lab-on-chip device for impedimetric measurements of D-dimers in whole blood
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Assembly of a polymer lab-on-chip device for impedimetric measurements of D-dimers in whole blood

机译：组装用于全血中D-二聚体阻抗测定的聚合物片上实验室设备

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摘要

This paper reports the development and characterisation of an assembly technology for a polymer lab-on-chip. The system consists of a 150 μm deep hot embossed microfluidic channel in polycarbonate and Au electrodes fabricated separately by photolithography on polyethylenenaphthalate. The system is designed for impedimetric immunoassay detection in whole blood. Electrode layer and microfluidic substrate are joined by means of a 50 μm thick double-sided medical grade adhesive tape, adjusted with an optical alignment system. The bond proved to be liquid tight at room temperature. An alignment accuracy of 34 μm (+/- 19 μm) evaluated over a set of 23 samples, was achieved. The effect of alignment accuracy of the intermediate adhesive film on whole blood flow properties in the device is studied. Already an alignment error of 70 μm increases the flushing out time of whole blood by approximately 20%.
机译：本文报告了聚合物片上实验室组装技术的发展和特性。该系统由在聚碳酸酯中的150μm深的热压纹微流体通道和在聚萘二甲酸乙二醇酯上通过光刻分别制造的Au电极组成。该系统设计用于全血中的阻抗测定。电极层和微流体基材通过50μm厚的双面医用级胶带连接，并通过光学对准系统进行调整。该键在室温下证明是不透液的。在一组23个样品上获得的对准精度为34μm（+/- 19μm）。研究了中间粘合膜的对准精度对装置中全血流特性的影响。 70 µm的对准误差已经使全血的冲洗时间增加了大约20％。

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