• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文会议>Acta physica polonica A >Magnetic Heating by Tunable Arrays of Nanoparticles in Cancer Therapy
【24h】

Magnetic Heating by Tunable Arrays of Nanoparticles in Cancer Therapy

机译：可调疗法的纳米粒子在癌症治疗中的磁加热。

获取原文
获取原文并翻译 | 示例
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Detailed knowledge about the temperature distribution achieved in the target area is essential for the development of magnetic hyperthermia treatments. However, the temperature inhomogeneity was found in all local hyperthermia studies. As a consequence of the impossibility of guaranteeing the temperature and thus the thermal dose distribution, hyperthermia is never applied as a single treatment modality. We suggest a model that enables the calculations and optimization of the spatial-time distribution of the temperature in the target volume (i.e. tumor) caused by magnetically heated elements: (i) arrays of clusters of iron oxides magnetite (Fe_3O_4) magnetic nanoparticles, and (ii) arrays of magnetic needles. In order to find the spatial-time temperature distribution in tumor, the bioheat transfer equation is solved for the two above-mentioned arrays of magnetically heated sources embedded in the tumor. The temporal and spatial temperature distributions were calculated with regard to the effect of blood perfusion in the tumor. It is shown that a matrix of magnetic micro-needles injected in the tumor could provide rather uniform tumor heating with the center-edge temperature difference smaller than 3℃ at any times during the magnetic hyperthermia treatments. The temperature profiles can be suitably adjusted by a proper choice of the magnetic nanoparticles arrangement.
机译：有关在目标区域中达到的温度分布的详细知识对于开发磁性高温疗法至关重要。但是，在所有局部热疗研究中均发现温度不均匀。由于不可能保证温度以及因此不能保证热剂量分布，因此热疗从未被用作单一治疗方式。我们建议一个模型，该模型能够计算和优化由磁加热元素引起的目标体积（即肿瘤）中温度的时空分布：（i）氧化铁磁铁矿（Fe_3O_4）磁性纳米粒子簇的阵列，以及（ii）磁针阵列。为了找到肿瘤中的时空温度分布，对嵌入在肿瘤中的上述两个磁加热源阵列求解了生物热传递方程。关于肿瘤中血液灌注的影响，计算了时间和空间温度分布。结果表明，在磁性热疗过程中，在任何时候注入的磁性微针基质都可以提供相当均匀的肿瘤加热，且中心边缘温度差在任何时候均小于3℃。可以通过适当选择磁性纳米颗粒排列来适当地调节温度分布。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号