Modified PSWM for RNA editing sites search

机译：修改后的PSWM用于RNA编辑位点搜索

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The computational method for RNA editing sites search is described. In RNA sequence ADAR ferments convert adenosine (A) into inosine (I), which in turn is read as guanosine (G), and increase transcriptomic diversity. We developed modification of PSWM method that includes information about pairwise correlations between nucleotides in ADAR editing site context. This method was used for in-silico discovery of potential RNA editing sites in deep sequencing RNA data.

机译：描述了用于RNA编辑位点搜索的计算方法。在RNA序列中，ADAR发酵将腺苷（A）转化为肌苷（I），后者又被称为鸟苷（G），并增加了转录组学多样性。我们开发了PSWM方法的修改，其中包括有关ADAR编辑位点上下文中核苷酸之间成对相关性的信息。此方法用于在计算机上发现RNA深度测序中潜在的RNA编辑位点。

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来源
《Advances in biomedical research》|2010年|p.475-477|共3页
会议地点 Cambridge(GB);Cambridge(GB);Cambridge(GB);Cambridge(GB);Cambridge(GB);Cambridge(GB)
作者
SHTOKALO D.; NECHKIN S.; EREMINA T.; CHEREMUSHKIN E.; ST. LAURENT G.;
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作者单位

Ershov Institute of Informatics Systems Lavrentjiev ave. 6, Novosibirsk, 630090rnRUSSIA;

Ershov Institute of Informatics Systems Lavrentjiev ave. 6, Novosibirsk, 630090rnRUSSIA;

Ershov Institute of Informatics Systems Lavrentjiev ave. 6, Novosibirsk, 630090rnRUSSIA;

Ershov Institute of Informatics Systems Lavrentjiev ave. 6, Novosibirsk, 630090rnRUSSIA;

Ershov Institute of Informatics Systems Lavrentjiev ave. 6, Novosibirsk, 630090rnRUSSIA;

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原文格式 PDF
正文语种 eng
中图分类生物医学工程;
关键词
ADAR editing; context score; matrix; position weight matrices; PSWM; RNA editing;

机译：ADAR编辑；上下文得分；矩阵;位置权重矩阵PSWM； RNA编辑;

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专利

1. Effects of antidepressants on GluR2 Q/R site-RNA editing in modified HeLa cell line. [J] . Sawada J, Yamashita T, Aizawa H Neuroscience Research: The Official Journal of the Japan Neuroscience Society . 2009,第3期

机译：抗抑郁药对修饰的HeLa细胞系GluR2 Q / R位点-RNA编辑的影响。
2. Identification of RNA editing sites in chloroplast transcripts from the maternal and paternal progenitors of tobacco (Nicotiana tabacum): Comparative analysis shows the involvement of distinct trans-factors for ndhB editing [J] . Sasaki T, Yukawa Y, Miyamoto T, Molecular biology and evolution . 2003,第7期

机译：烟草（Nicotiana tabacum）母代和父代叶绿体转录本中RNA编辑位点的鉴定：对比分析显示了不同的反式因子参与ndhB编辑
3. Modeling Sites of RNA Editing as a Fifth Nucleotide State Reveals Progressive Loss of Edited Sites from Angiosperm Mitochondria [J] . Jeffrey P. Mower Molecular Biology and Evolution . 2008,第1期

机译：RNA编辑作为第五种核苷酸状态的建模位点揭示了被子植物线粒体的编辑位点逐渐丢失
4. Modified PSWM for RNA editing sites search [C] . SHTOKALO D., NECHKIN S., EREMINA T., WSEAS International Conference on Mathematical Biology and Ecology . 2010

机译：用于RNA编辑网站的修改后的PSWM搜索
5. Structural Engineering of Adenosine Deaminases Acting on RNA with Chemically Modified Guide RNAs for Site-Directed RNA Editing [D] . Monteleone, Leanna Rose. 2020

机译：腺苷脱胺酶的结构工程，用化学改性导向RNA作用于基于化学改性的rNA的定向RNA编辑
6. Involvement of a site-specific trans-acting factor and a common RNA-binding protein in the editing of chloroplast mRNAs: development of a chloroplast in vitro RNA editing system [O] . Tetsuro Hirose, Masahiro Sugiura 2001

机译：位点特异性反式作用因子和常见的RNA结合蛋白参与叶绿体mRNA的编辑：叶绿体体外RNA编辑系统的开发
7. Effects of antidepressants on GluR2 Q/R site-RNA editing in modified HeLa cell line. [O] . 相澤, 仁志, アイザワ, ヒトシ, Aizawa, Hitoshi, 2009

机译：抗抑郁药对修饰的HeLa细胞系GluR2 Q / R位点RNA编辑的影响。

Modified PSWM for RNA editing sites search

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