首页> 外文会议>Optical diagnostics and sensing XVIII: Toward Point-of-Care Diagnostics >Photodynamic diagnostics of stress-induced gastrointestinal neoplasia in laboratory animals using 5-aminolevulinic acid and Al-phthalocyanine
【24h】

Photodynamic diagnostics of stress-induced gastrointestinal neoplasia in laboratory animals using 5-aminolevulinic acid and Al-phthalocyanine

机译:使用5-氨基乙酰丙酸和铝酞菁对实验动物进行应激诱导的胃肠道肿瘤的光动力学诊断

获取原文
获取原文并翻译 | 示例

摘要

The main research objective is the development of innovative optical technologies for sensitive diagnosis of early stages of development of stomach cancer and monitoring of stress-induced appearance and development of tumors of the gastrointestinal tract by applying endogenous and exogenous fluorescence spectroscopy modalities. Different mechanisms solely and in combination for evaluation of the joint impact of bioenvironmental factors (stress, Helicobacter pillory, exo-toxins in the food, water, soil and air) were applied to induce gastrointestinal tract (GIT) neoplasia in rats. The transformation of damaged areas of the stomach mucosa into malignancies in all parts of gastrointestinal tract were detected using exogenous fluorescence of photosensitizers - 5-aminolevulinic acid (5-ALA) and aluminum phthalocyanine (Al-Pc). Fluorescent mapping of different organs (liver, spleen, lungs, brain) also was developed - to evaluate the distribution of the photosensitizers in the whole body on the second hour after photosensitizer application by intravenous injection. Fiber-optic probe was used to measure the organs investigated. Fluorescence spectra were detected by microspectrometer USB4000 (OceanOptics Inc., USA), and FS405 LED source on 405 nm was used as excitation source for both types of photosensitizers applied. Diagnostically-important parameters of oximetry, optical coherence tomography and speckle-imaging of the microcirculation of the stomach were also evaluated, to evaluate changes in the blood flow and vascular architecture, during the formation of the initial phases of the neoplasm development.
机译:主要研究目标是开发创新的光学技术,以通过应用内源性和外源性荧光光谱法对胃癌发展的早期阶段进行敏感诊断,并监测应激诱导的胃肠道肿瘤的发生和发展。单独或组合使用不同的机制来评估生物环境因素(压力,幽门螺杆菌,食物,水,土壤和空气中的外毒素)的联合影响,以诱导大鼠胃肠道(GIT)瘤形成。使用光敏剂-5-氨基乙酰丙酸(5-ALA)和铝酞菁(Al-Pc)的外源荧光检测了胃粘膜受损区域在胃肠道所有部位的恶性转化。还开发了不同器官(肝,脾,肺,脑)的荧光图谱,以评估通过静脉注射光敏剂后第二小时光敏剂在全身的分布。光纤探头用于测量所研究的器官。用显微光谱仪USB4000(OceanOptics Inc.,美国)检测荧光光谱,并且将405nm的FS405LED光源用作所施加的两种类型的光敏剂的激发源。还评估了血氧饱和度,光学相干断层扫描和胃微循环的斑点成像等重要的诊断参数,以评估在肿瘤发展初期阶段形成过程中血流和血管结构的变化。

著录项

  • 来源
  • 会议地点 San Francisco(US)
  • 作者单位

    Institute of Electronics, Bulgarian Academy of Sciences,72 Tsarigradsko chaussee Blvd., 1784 Sofia, Bulgaria,Saratov National Research State University, 83 Astrachanskaya str., 410012 Saratov, Russia;

    Saratov National Research State University, 83 Astrachanskaya str., 410012 Saratov, Russia;

    Saratov State Medical University, 112 Bol'shaya Kazach'ya str., 410012 Saratov, Russia;

    Institute of Organic Chemistry with Centre of Phytochemistry, Bulgarian Academy of Sciences,9 Acad. G. Bonchev Blvd., 1113 Sofia, Bulgaria;

    Institute of Organic Chemistry with Centre of Phytochemistry, Bulgarian Academy of Sciences,9 Acad. G. Bonchev Blvd., 1113 Sofia, Bulgaria;

    Saratov National Research State University, 83 Astrachanskaya str., 410012 Saratov, Russia;

    Saratov National Research State University, 83 Astrachanskaya str., 410012 Saratov, Russia;

    Saratov National Research State University, 83 Astrachanskaya str., 410012 Saratov, Russia;

    Saratov National Research State University, 83 Astrachanskaya str., 410012 Saratov, Russia;

    Saratov National Research State University, 83 Astrachanskaya str., 410012 Saratov, Russia;

    Saratov National Research State University, 83 Astrachanskaya str., 410012 Saratov, Russia;

    Saratov National Research State University, 83 Astrachanskaya str., 410012 Saratov, Russia;

    Institute of Electronics, Bulgarian Academy of Sciences,72 Tsarigradsko chaussee Blvd., 1784 Sofia, Bulgaria;

  • 会议组织
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    exogenous fluorescence; stomach cancer; stress-induced neoplasia; photodiagnosis;

    机译:外源荧光胃癌;应激性肿瘤光诊断;

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号