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首页> 外文会议>DNA computing and molecular programming >Design of a Functional Nanomaterial with Recognition Ability for Constructing Light-Driven Nanodevices
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Design of a Functional Nanomaterial with Recognition Ability for Constructing Light-Driven Nanodevices

机译：具有识别能力的功能纳米材料的设计，以构建光驱动纳米器件。

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摘要

An artificial macromolecule (foldamer) was designed as a novel nanomaterial with the backbone of phosphodiester and the side chain of functional molecules and nucleobases. The functional molecules tethered on D-threoninol and the nucleosides on D-ribose can be lined up with any sequence and ratio by using standard phosphoramidite chemistry. The nucleobases that form Watson-Crick base pairs provide the sequence recognition which is required for constructing complicate nanostructures. The multiple functional molecules give applicable and advanced functions such as photoresponsiveness when azobenzenes were used. Unexpectedly, a stable double helix was formed even in the case that the ratio of azobenzene molecules and base pairs was as high as 2:1. More interestingly, this artificial duplex showed high sequence specificity: the stability decreased greatly when a mismatched base pair was present. Furthermore, the formation and dissociation of the constructed artificial duplex were reversibly and completely modulated with light irradiation. By using this new nanomaterial, a variety of functional nanostructures and nanodevices are promising to be designed.
机译：人工高分子（折叠）被设计为一种新型的纳米材料，具有磷酸二酯的骨架和功能分子和核碱基的侧链。通过使用标准亚磷酰胺化学方法，可以将束缚在D-苏氨酸上的功能分子和D-核糖上的核苷按任何序列和比例排列。形成沃森-克里克碱基对的核碱基可提供构建复杂纳米结构所需的序列识别。当使用偶氮苯时，多功能分子可提供适用的高级功能，例如光响应性。出乎意料的是，即使偶氮苯分子与碱基对的比例高达2：1，也会形成稳定的双螺旋。更有趣的是，这种人工双链体显示出高序列特异性：当存在不匹配的碱基对时，稳定性大大降低。此外，所构建的人工双链体的形成和解离通过光照射可逆地和完全地调节。通过使用这种新的纳米材料，有望设计出各种功能纳米结构和纳米器件。

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  • 来源
  • 会议地点 Hong Kong(CN);Hong Kong(CN)
  • 作者

    Xingguo Liang; Toshio Mochizuki; Taiga Fujii; Hiromu Kashida; Hiroyuki Asanuma;

  • 作者单位

    Department of Molecular Design and Engineering, Graduate School of Engineering, Nagoya University, Chikusa, Nagoya 464-8603, Japan;

    Department of Molecular Design and Engineering, Graduate School of Engineering, Nagoya University, Chikusa, Nagoya 464-8603, Japan;

    Department of Molecular Design and Engineering, Graduate School of Engineering, Nagoya University, Chikusa, Nagoya 464-8603, Japan;

    Department of Molecular Design and Engineering, Graduate School of Engineering, Nagoya University, Chikusa, Nagoya 464-8603, Japan;

    Department of Molecular Design and Engineering, Graduate School of Engineering, Nagoya University, Chikusa, Nagoya 464-8603, Japan, Core Research for Evolution Science and Technology (CREST), Japan Science and Technology Agency (JST), Kawaguchi, Saitama 332-0012, Japan;

  • 会议组织
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 生物工程学（生物技术）;
  • 关键词

    nanodevice; nucleobase; photoregulation; hybridization;

    机译：纳米器件核碱基光调节；杂交;

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