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Evaluation of high intensity focused ultrasound ablation of prostate tumor with hyperpolarized 13C imaging biomarkers

机译：超极化13C成像生物标记物评估前列腺肿瘤的高强度聚焦超声消融

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摘要

Real-time hyperpolarized (HP) ~(13)C MR can be utilized during high-intensity focal ultrasound (HIFU) therapy to improve treatment delivery strategies, provide treatment verification, and thus reduce the need for more radical therapies for low-and intermediate-risk prostate cancers. The goal is to develop imaging biomarkers specific to thermal therapies of prostate cancer using HIFU, and to predict the success of thermal coagulation and identify tissues potentially sensitized to adjuvant treatment by sub-ablative hyperthermic heat doses. Mice with solid prostate tumors received HIFU treatment (5.6 MHz, 160W/cm~2, 60 s), and the MR imaging follow-ups were performed on a wide-bore 14T microimaging system. ~(13)C-labeled pyruvate and urea were used to monitor tumor metabolism and perfusion accordingly. After treatment, the ablated tumor tissue had a loss in metabolism and perfusion. In the regions receiving sub-ablative heat dose, a time-dependent change in metabolism and perfusion was observed. The untreated regions behaved as a normal untreated TRAMP prostate tumor would. This promising preliminary study shows the potential of using ~(13)C MR imaging as biomarkers of HIFU/thermal therapies.
机译：实时超极化（HP）〜（13）C MR可在高强度聚焦超声（HIFU）治疗期间使用，以改善治疗提供策略，提供治疗验证，从而减少对中，低剂量的更彻底治疗的需求-高危前列腺癌。目标是开发使用HIFU的前列腺癌热疗法特异的成像生物标记，并预测热凝的成功并鉴定可能通过亚烧蚀性高温热剂量对辅助治疗敏感的组织。患有实体前列腺肿瘤的小鼠接受HIFU治疗（5.6 MHz，160W / cm〜2，60 s），并在宽口径14T微成像系统上进行MR成像随访。 〜（13）C标记的丙酮酸和尿素被用于相应地监测肿瘤的代谢和灌注。治疗后，消融的肿瘤组织代谢和灌注减少。在接受亚消融热剂量的区域，观察到了新陈代谢和灌注随时间的变化。未经治疗的区域表现为正常未经治疗的TRAMP前列腺肿瘤。这项有前途的初步研究表明，使用〜（13）C MR成像作为HIFU /热疗法的生物标志物的潜力。

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