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首页> 外文会议>European conference on biomaterials;ESB 2010 >Guidance channels for reconstruction of peripheral nerves - in vitro and in vivo trials
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Guidance channels for reconstruction of peripheral nerves - in vitro and in vivo trials

机译：重建周围神经的引导通道-体外和体内试验

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Nerve injuries occur with high frequency in conjunction with accidents involving fractures of either bones or soft tissue. Bridging a nerve gap is a serious challenge, which is regarded as successful if a full functionality of an injured limb or affected tissue is recovered. Autograft transplantation has been commonly used for nerve restoration in medical practice since long, and despite several obvious disadvantages and limitations it is still recognized as the best solution [1]. Another method that recently gains of its importance is bridging the lesion with a guidance channel. That would at least secure a space for an injured nerve growth, guide growing axons into proper direction and, since they usually contain biologically active growth factors, stimulate axons propagation. This very promising technique for bridging large gaps requires employment of materials with perfect biocompatibility, specific mechanical properties and controlled degradability. A number of materials and compositions were reported beneficial for this application, nevertheless none of them fully satisfied the requirements [2]. This report presents work done in order to evaluate physicochemical and in vitro suitability of used polymers as biomaterials, develop a fabrication method of guidance tubes of predetermined properties, as well as in vivo trials of peripheral nerve reconstruction on rat model.
机译：伴随骨头或软组织骨折的事故，神经受伤频繁发生。弥合神经间隙是一项严峻的挑战，如果恢复了受伤肢体或受影响组织的全部功能，这将被认为是成功的。自长期以来，自体移植一直在医学实践中用于神经修复，尽管有几个明显的缺点和局限性，但仍被认为是最佳的解决方案[1]。最近获得其重要性的另一种方法是用引导通道桥接病变。这至少将确保受伤的神经生长的空间，将生长的轴突引导到正确的方向，并且由于它们通常包含生物活性生长因子，因此可以刺激轴突的繁殖。这种弥合大间隙的非常有前途的技术要求使用具有完美生物相容性，特定机械性能和可控制降解性的材料。据报道，许多材料和成分对该应用有益，但是它们都不完全满足要求[2]。本报告介绍了完成的工作，以评估用作聚合物的生物材料的理化和体外适应性，开发具有预定特性的导管的制造方法，以及在大鼠模型上进行周围神经重建的体内试验。

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