Time-gated real-time bioimaging system using multicolor microsecond- lifetime silica nanoparticles

机译：使用多色微秒寿命二氧化硅纳米粒子的时间门控实时生物成像系统

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In advanced cytometry, a fundamental challenge for rapid specific detection of rare-event micro-organisms is the autofluorescence noise from the complex biological samples. Time-gated luminescence can effectively discriminate labeled cells from autofluorescence background. Recently, a real-time true-colour time-gated luminescence microscopy system has been developed based on the synchronization of a solid-state excitation source and a super-fast optical shutter. We also developed a variety of ultra-bright silica nano-biolabels with multiple luminescence colours and controllable lifetimes in microsecond range. These developments allowed the development of an advanced cell analysis system for real-time background-free imaging and rare-event counting of microsecond-lifetime multi-colour labelled water-borne pathogens.

机译：在先进的细胞计数技术中，对稀有事件微生物进行快速特异性检测的基本挑战是来自复杂生物样品的自发荧光噪声。时间门控发光可以有效地将标记的细胞与自体荧光背景区分开。近来，基于固态激发源和超快光学快门的同步，已经开发了实时真彩色时间门控发光显微镜系统。我们还开发了多种具有多种发光颜色和可控制寿命（微秒范围）的超亮二氧化硅纳米生物标签。这些发展使先进的细胞分析系统得以开发，用于实时无背景成像以及微秒寿命多色标记的水性病原体的罕见事件计数。

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来源
《Imaging, manipulation, and analysis of biomolecules, cells, and tissues VIII》|2010年|P.756819.1-756819.12|共12页
会议地点 San Francisco CA(US)
作者
Dayong Jin; James Piper; Jingli Yuan; Robert Leif;
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作者单位

MQ Photonics Centre, Faculty of Science, Macquarie University, NSW 2109, Sydney, Australia;

rnMQ Photonics Centre, Faculty of Science, Macquarie University, NSW 2109, Sydney, Australia;

rnState Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian 116012, P. R. China;

rnNewport Instruments, 5648 Toyon Road, San Diego, CA, USA 92115-1022;

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会议组织
原文格式 PDF
正文语种 eng
中图分类医用物理学;
关键词
time-gated luminescence; real-time imaging; silica nanoparticle; europium; terbium; lanthanide; waterborne; pathogen; microscopy; lifetime; autofluorescence;

机译：定时发光实时成像；二氧化硅纳米粒子铕;铽;镧系元素水性病原;显微镜一生;自发荧光;

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专利

1. Preparation and time-gated luminescence bioimaging application of ruthenium complex covalently bound silica nanoparticles [J] . Song Cuihong, Ye Zhiqiang, Wang Guilan, Talanta: The International Journal of Pure and Applied Analytical Chemistry . 2009,第1期

机译：钌配合物共价键合二氧化硅纳米粒子的制备及其时控发光生物成像应用
2. Real-Time Monitoring of ATP-Responsive Drug Release Using Mesoporous-Silica-Coated Multicolor Upconversion Nanoparticles [J] . Lai Jinping, Shah Birju R., Zhang Yixiao, ACS nano . 2015,第5期

机译：使用中孔二氧化硅涂层的多色上转换纳米粒子实时监测ATP响应药物的释放
3. Alizarin Complexone Functionalized Mesoporous Silica Nanoparticles: A Smart System Integrating Glucose-Responsive Double-Drugs Release and Real-Time Monitoring Capabilities [J] . Zou Zhen, He Dinggeng, Cai Linli, ACS applied materials & interfaces . 2016,第13期

机译：茜素配合物功能化的介孔二氧化硅纳米粒子：集成了葡萄糖反应性双药物释放和实时监测功能的智能系统。
4. Time-gated real-time bioimaging system using multicolor microsecond-lifetime silica nanoparticles [C] . Dayong Jin, James Piper, Jingli Yuan, SPIE Conference on Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues . 2010

机译：使用多色微秒寿命二氧化硅纳米粒子的时间门控实时生物分析系统
5. Engineering Multifunctional Mesoporous Silica Nanoparticles for Stimuli-responsive Drug Delivery and Bioimaging =設計多功能介孔二氧化矽奈米粒子--用於刺激反應性藥物遞送和生物成像 [D] . Cheng, Chi-An. 2020

机译：Engineering Multifunctional Mesoporous Silica Nanoparticles for Stimuli-responsive Drug Delivery and Bioimaging =设计多功能介孔二氧化矽奈米粒子--用于刺激反应性药物递送和生物成像
6. Real-Time Monitoring of ATP-Responsive Drug Release Using Mesoporous-Silica-Coated Multicolor Upconversion Nanoparticles [O] . Jinping Lai, Birju P. Shah, Yixiao Zhang, -1

机译：使用中孔二氧化硅涂层的多色上转换纳米粒子实时监测ATP响应药物的释放
7. Real-Time Monitoring of ATP-Responsive Drug Release Using Mesoporous-Silica-Coated Multicolor Upconversion Nanoparticles [O] . Jinping Lai, Birju P. Shah, Yixiao Zhang, 2015

机译：使用中孔二氧化硅涂覆的多色上转化纳米粒子实时监测ATP响应药物释放

Time-gated real-time bioimaging system using multicolor microsecond- lifetime silica nanoparticles

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