Mechanical Response of Embryonic Stem Cells Using Haptics-Enabled Atomic Force Microscopy

机译：触觉使能原子力显微镜对胚胎干细胞的机械反应。

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Mechanical manipulation and characterization of biological cells is currently one of the most exciting research areas in the field of medical robotics applied to cellular level interactions. While biologists are able to ascertain the change in cell status visually based on mRNA or proteins markers, it is often qualitative and difficult to quantitatively define the outcome of a cell progression during differentiation. Consequently, we propose to develop a haptics-enabled atomic force microscopy system to mechanically manipulate and characterize an individual cell. The haptic feedback interface proposed in this paper comprises of a PHANToM haptic feedback device combined with the atomic force microscope (AFM). The system has the capability of measuring forces in nN range and provides a haptic display of the cell indentation forces in real time. We conducted studies on mouse embryonic stem cells (mESC) and our experimental results indicate that the mechanical property of undifferentiated mESC differs from differenttiated mESC.

机译：目前，生物细胞的机械操作和表征是应用于细胞水平相互作用的医疗机器人领域最激动人心的研究领域之一。虽然生物学家能够根据mRNA或蛋白质标记物目视确定细胞状态的变化，但通常在定性上很难量化分化过程中细胞进展的结果。因此，我们建议开发一种具有触觉功能的原子力显微镜系统，以机械方式操纵和表征单个细胞。本文提出的触觉反馈接口包括结合了原子力显微镜（AFM）的PHANToM触觉反馈设备。该系统具有在nN范围内测量力的能力，并实时提供触觉显示单元压痕力。我们对小鼠胚胎干细胞（mESC）进行了研究，我们的实验结果表明未分化的mESC的机械性能与分化的mESC有所不同。

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《International symposium on experimental robotics;ISER'11; 20080713-16;20080713-16; Athens(GR);Athens(GR)》|2008年|P.261-269|共9页
会议地点 Athens(GR);Athens(GR)
作者
Anand Pillarisetti; Carol Keefer; Jaydev P. Desai;
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Robotics, Automation, Manipulation, and Sensing (RAMS) Laboratory University of Maryland, College Park, USA;

Department of Animal and Avian Sciences University of Maryland, College Park, USA;

Robotics, Automation, Manipulation, and Sensing (RAMS) Laborator;

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正文语种 eng
中图分类机器人技术;
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1. Atomic Force Microscopy Mechanical Mapping of Micropatterned Cells Shows Adhesion Geometry-Dependent Mechanical Response on Local and Global Scales [J] . Rigato Annafrancesca, Rico Felix, Eghiaian Frederic, ACS nano . 2015,第6期

机译：微图案化细胞的原子力显微镜机械制图显示局部和全局尺度上的粘附几何依赖的机械响应。
2. Elasticity of Human Embryonic Stem Cells as Determined by Atomic Force Microscopy [J] . Robert Kiss, Henry Bock, Steve Pells, Journal of biomechanical engineering. . 2011,第10期

机译：通过原子力显微镜确定的人类胚胎干细胞的弹性。
3. Quantitative analysis of mechanical force required for cell extrusion in zebrafish embryonic epithelia Quantitative analysis of mechanical force required for cell extrusion in zebrafish embryonic epithelia Quantitative analysis of mechanical force required for cell extrusion in zebrafish embryonic epithelia [J] . Yoichiroh Hosokawa, Sohei Yamada, Takaaki Matsui, Biology Open . 2017,第10期

机译：斑马鱼胚胎上皮细胞挤压所需的机械力的定量分析斑马鱼胚胎上皮细胞挤压所需的机械力的定量分析斑马鱼胚胎上皮细胞挤压所需的机械力的定量分析
4. Mechanical Response of Embryonic Stem Cells Using Haptics-Enabled Atomic Force Microscopy [C] . Anand Pillarisetti, Carol Keefer, Jaydev P. Desai International Symposium on Experimental Robotics . 2009

机译：胚胎干细胞使用触觉的原子力显微镜的机械响应
5. Control of cell fate decisions of embryonic stem cells by mechanical forces. [D] . Chowdhury, Farhan Hyder. 2011

机译：通过机械力控制胚胎干细胞的细胞命运决定。
6. Atomic Force Microscopy Mechanical Mapping of Micropatterned Cells Shows Adhesion Geometry-Dependent Mechanical Response on Local and Global Scales [O] . Annafrancesca Rigato, Felix Rico, Frédéric Eghiaian, -1

机译：微模式细胞的原子力显微镜机械制图显示局部和全局尺度上的粘附几何依赖的机械响应。
7. Atomic Force Microscopy Mechanical Mapping of Micropatterned Cells Shows Adhesion Geometry-Dependent Mechanical Response on Local and Global Scales. [O] . Rigato Annafrancesca, Rico Felix, Eghiaian Frédéric, 2015

机译：微图案化细胞的原子力显微镜机械制图在局部和全局尺度上显示出粘附几何相关的机械响应。

Mechanical Response of Embryonic Stem Cells Using Haptics-Enabled Atomic Force Microscopy

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