Activation Mechanism and Modification Kinetics of Chinese Hamster Dihydrofolate Reductase by p-Chlormercuribenzoate

机译：对氯甲基苯甲酸酯对中国仓鼠二氢叶酸还原酶的激活机理及修饰动力学

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Substrate effects on the activation kinetics of Chinese hamster dihydrofolate reductase by p-chloromercuribenzoate (pCMB) have been studied. On the basis of the kinetic equation of substrate reaction in the presence of pCMB, all modification kinetic constants for the free enzyme, enzyme-substrate binary and ternary complexes have been determined. The results of the present study indicate that the modification of Chinese hamster dihydrofolate reductase by pCMB shows a single-phase kinetics, and changes in the enzyme activity and tertiary structure proceed simultaneously during the modification process.

机译：研究了底物对对氯mercuribenzoate（pCMB）激活中国仓鼠二氢叶酸还原酶动力学的影响。基于在pCMB存在下底物反应的动力学方程，已经确定了游离酶，酶-底物二元和三元复合物的所有修饰动力学常数。本研究结果表明，pCMB修饰中国仓鼠二氢叶酸还原酶表现出单相动力学，并且在修饰过程中酶活性和三级结构的变化同时进行。

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来源
《International symposium on mechanisms of enzymatic catalysis》|1998年|75-76|共2页
会议地点 Guilin(CN)
作者
Jia-Wei Wu; Zhi-Xin Wang;
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作者单位

National Laboratory of Biomacromolecules Institute of Biophysics,Academia Sinica Beijing 100101, P. R. China;

National Laboratory of Biomacromolecules Institute of Biophysics,Academia Sinica Beijing 100101, P. R. China;

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原文格式 PDF
正文语种 eng
中图分类 Q-55;
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专利

1. Activation mechanism and modification kinetics of Chinese hamster dihydrofolate reductase by p-chloromercuribenzoate [J] . Wu JW., Wang ZX. The Biochemical Journal . 1998,第Pta1期

机译：对氯汞苯甲酸对中国仓鼠二氢叶酸还原酶的激活机理和修饰动力学
2. Activation mechanism and modification kinetics of Chinese hamster dihydrofolate reductase by p-chloromercuribenzoate. [J] . Wu JW, Wang ZX The Biochemical Journal . 1998,第Pta1期

机译：对氯巯基苯甲酸酯对中国仓鼠二氢叶酸还原酶的激活机理和修饰动力学。
3. Activation mechanism and modification kinetics of Chinese hamster dihydrofolate reductase by p-chloromercuribenzoate [J] . Jia-Wei WU, Zhi-Xin WANG The biochemical journal . 1998,第1期

机译：对氯汞苯甲酸对中国仓鼠二氢叶酸还原酶的激活机理和修饰动力学
4. Activation Mechanism and Modification Kinetics of Chinese Hamster Dihydrofolate Reductase by p-Chlormercuribenzoate [C] . International symposium mechanisms of enzymatic catalysis . 1998

机译：P-Chlormercuribenzoate中国仓鼠二氢酚酸还原酶的活化机制及改性动力学
5. Investigation of the kinetic mechanism and the activation of methyl-coenzyme M reductase: The catalyst for the final step in methanogenesis. [D] . Horng, Yih-Chern. 2003

机译：动力学机理和甲基辅酶M还原酶激活的研究：甲烷生成最后一步的催化剂。
6. Activation mechanism and modification kinetics of Chinese hamster dihydrofolate reductase by p-chloromercuribenzoate. [O] . J W Wu, Z X Wang 1998

机译：对氯汞苯甲酸对中国仓鼠二氢叶酸还原酶的激活机理和修饰动力学。
7. Activation mechanism and modification kinetics of Chinese hamster dihydrofolate reductase by p-chloromercuribenzoate. [O] . Wu, J W, Wang, Z X 1998

机译：对氯汞苯甲酸对中国仓鼠二氢叶酸还原酶的激活机理和修饰动力学。

Activation Mechanism and Modification Kinetics of Chinese Hamster Dihydrofolate Reductase by p-Chlormercuribenzoate

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