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首页> 外文会议>Mechanisms for Low-Light Therapy; Progress in Biomedical Optics and Imaging; vol.7 no.26 >Effects of low intensity laser irradiation during healing of infected skin lesions in the rat
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Effects of low intensity laser irradiation during healing of infected skin lesions in the rat

机译：低强度激光照射在大鼠感染性皮肤损伤愈合中的作用

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摘要

Purpose: To determine the effect of low intensity laser therapy (LILT) on healing of infected skin wounds in the rat. Methods: Wounds on the dorsum of Sprague-Dawley rats (14 per group) were inoculated or sham-inoculated with P. aeruginosa. Wounds were irradiated or sham-irradiated three times weekly from Day 1-19 using 635nm or 808nm diode lasers at radiant exposure of 1 or 20 J/cm~2 delivered in continuous wave (CW) or at an intensity modulation frequency of 3800Hz. Wound area and bacterial growth were evaluated three times weekly. Results: CW 808 nm (1 and 20 J/cm~2) irradiation generally delayed healing in acute wounds. However, from Day 10 onwards CW 808 nm (1 J/cm~2 and 20 J/cm~2) and 808 nm 3800 Hz (1 J/cm~2) irradiation improved healing in inoculated wounds. Healing in acute wounds improved using 635 nm irradiation at low radiant exposure (1 J/cm~2); however, using 635 nm irradiation at high radiant exposure (20 J/cm~2) delayed healing. Bacterial balance in wounds was significantly altered using 635 nm (20 J/cm~2) and CW 808 nm irradiation (1 and 20 J/cm~2). Conclusion: Clearing wounds of normal flora was not associated with improved healing. Proliferation of staphylococcal species in wounds was associated with delayed healing.
机译：目的：确定低强度激光疗法（LILT）对大鼠感染皮肤伤口的愈合作用。方法：用铜绿假单胞菌接种或假接种Sprague-Dawley大鼠的背部伤口（每组14只）。从第1-19天起，每周使用635nm或808nm二极管激光器以连续波（CW）的1或20 J / cm〜2的辐射暴露或3800Hz的强度调制频率对伤口进行每周3次的照射或假照射。每周评估伤口面积和细菌生长3次。结果：CW 808 nm（1和20 J / cm〜2）照射通常会延迟急性伤口的愈合。但是，从第10天起，连续波808 nm（1 J / cm〜2和20 J / cm〜2）和808 nm 3800 Hz（1 J / cm〜2）辐照改善了接种伤口的愈合。在低辐射照射（1 J / cm〜2）下使用635 nm辐照可以改善急性伤口的愈合；但是，在高辐射（20 J / cm〜2）下使用635 nm辐射会延迟愈合。 635 nm（20 J / cm〜2）和CW 808 nm照射（1和20 J / cm〜2）显着改变了伤口中的细菌平衡。结论：清除正常菌群伤口与改善愈合没有关系。葡萄球菌在伤口中的扩散与愈合的延迟有关。

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