Stability evaluation of antigens from Neisseria meningitides serogroup B adsorbed on anionic PLG microparticles

机译：脑膜炎奈瑟氏球菌血清群B抗原吸附在阴离子PLG微粒上的稳定性评估

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The stability of three proteins from Neisseria Meningitidis serogroup B proteins (MenB) formulated on polylactide co-glycolyde microparticles (PLG) was evaluated. Integrity of proteins released from microparticles stored at 4 and 25 degrees Celsius was evaluated at two weeks, one month, three months and 18 months by SDS-PAGE and Western blot. The immunogenicity of the formulation was assessed in mice after four months and compared to freshly made formulations. The results suggest that the three MenB proteins formulated with PLG microparticles is a stable formulation.

机译：评价了在聚丙交酯-共-糖微粒（PLG）上配制的脑膜炎奈瑟氏球菌血清B蛋白（MenB）的三种蛋白的稳定性。通过SDS-PAGE和Western blot在2周，1个月，3个月和18个月评估从4摄氏度和25摄氏度下存储的微粒释放的蛋白质的完整性。在四个月后在小鼠中评估制剂的免疫原性，并将其与新鲜制备的制剂进行比较。结果表明，用PLG微粒配制的三种MenB蛋白是稳定的制剂。

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《Controlled Release Society Annual Meeting and Exposition》|2007年|P.524-525|共2页
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J. Kazzaz; M. Ugozzoli; P. Malyala; J. Chesko; M. Singh; D. OHagan;
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中图分类生物工程学（生物技术）;
关键词
vaccines; microparticles; protein adsorption;

机译：疫苗;微粒;蛋白质吸附;

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专利

1. Characterization of antigens adsorbed to anionic PLG microparticles by XPS and TOF-SIMS. [J] . Chesko J, Kazzaz J, Ugozzoli M, Journal of pharmaceutical sciences. . 2008,第4期

机译：XPS和TOF-SIMS表征吸附到阴离子PLG微粒上的抗原。
2. Adsorption of a novel recombinant glycoprotein from HIV (Env gp120dV2 SF162) to anionic PLG microparticles retains the structural integrity of the protein, whereas encapsulation in PLG microparticles does not. [J] . Singh M, Chesko J, Kazzaz J, Pharmaceutical research . 2004,第12期

机译：来自HIV（Env gp120dV2 SF162）的新型重组糖蛋白对阴离子PLG微粒的吸附保留了蛋白质的结构完整性，而封装在PLG微粒中则没有。
3. Recombinant Neisseria surface protein A is a potential vaccine candidate against Neisseria meningitides serogroup B [J] . YingS., HeJ., YuM., Molecular medicine reports . 2014,第3期

机译：重组奈瑟氏球菌表面蛋白A是针对脑膜炎奈瑟菌血清群B的潜在疫苗候选
4. Stability evaluation of antigens from Neisseria meningitides serogroup B adsorbed on anionic PLG microparticles [C] . J. Kazzaz, M. Ugozzoli, P. Malyala, Controlled Release Society Annual Meeting and Exposition . 2007

机译：黑色PLG微粒吸附着Neisseria脑膜训练剂血清群B的抗原的稳定性评价
5. Application of Multiple-Locus Variable Number Tandem Repeat Analysis to Identify Outbreak-Associated Neisseria meningitides Serogroup C Sequence Type 4821 in China [O] . Xiaoying Shan, Haijian Zhou, Ji Zhang, 2015

机译：多位点可变数串联重复分析在中国暴发性脑膜炎奈瑟氏球菌血清群C序列4821型识别中的应用
6. Meningitis Caused by Neisseria meningitides Serogroup B in a Newborn in China [O] . Yajuan Wang 2016

机译：脑膜炎由Neisseria脑膜训练剂血清群B在新出生中的血清群B

Stability evaluation of antigens from Neisseria meningitides serogroup B adsorbed on anionic PLG microparticles

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