Multi-modal neural microprobe integrating silicon microelectrodes and polymeric microchannels

机译：集成硅微电极和聚合物微通道的多模式神经微探针

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Direct interfacing with brain tissues for neuroscience, neural prosthetics, and local treatment of brain diseases necessitates the implantation of arrays of electrodes to stimulate, record electrical activity, and deliver drugs to specific locations in the brain. Here, we present novel elongated multi-modal neural microprobe capable of simultaneously recording the electrical activity of the brain and delivering drugs to the diagnosed location through polymeric microchannel embedded on top of the electrode. The functionality of the electrical part of the microprobe was tested in rats and high frequency spikes were recorded.

机译：为了与神经科学，神经修复术和脑部疾病进行局部治疗直接与脑组织相接，需要植入电极阵列以刺激，记录电活动并将药物输送到脑中的特定位置。在这里，我们提出了新颖的细长型多模态神经微探针，它能够同时记录大脑的电活动，并通过嵌入电极顶部的聚合物微通道将药物输送到诊断位置。在大鼠中测试了微探针的电气部分的功能，并记录了高频尖峰。

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《International Conference on Microelectronics》|2013年|1-5|共5页
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Hajj-Hassan Mohamad; Hajj-Hassan Hussein; Ghafar-Zadeh Ebrahim;
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Brain machine interfaces; drug delivery; microchannels; neural probes;

机译：脑机接口;药物输送;微通道;神经探针;

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专利

1. Dielectric impedance spectroscopy of polymer-coated microelectrodes for adsorption monitoring of proteins within polymer microchannels [J] . Kechadi Mohammed, Chaal Lila, Tribollet Bernard, Journal of Electroanalytical Chemistry: An International Journal Devoted to All Aspects of Electrode Kinetics, Interfacial Structure, Properties of Electrolytes, Colloid and Biological Electrochemistry . 2015,第Null期

机译：聚合物涂层微电极的介电阻抗谱，用于监测聚合物微通道内蛋白质的吸附
2. On the fabrication parameters of buried microchannels integrated in in-plane silicon microprobes [J] . Z. Fekete, A. Pongracz, G. Morton, Materials science forum . 2013,第期

机译：集成在平面硅微探针中的掩埋微通道的制造参数
3. Integration of out-of-plane silicon dioxide microtubes, silicon microprobes and on-chip NMOSFETs by selective vapor-liquid-solid growth [J] . Takei K, Kawashima T, Kawano T, Journal of Micromechanics and Microengineering . 2008,第3期

机译：通过选择性的气液固生长来集成平面外二氧化硅微管，硅微探针和片上NMOSFET
4. Multi-modal neural microprobe integrating silicon microelectrodes and polymeric microchannels [C] . Hajj-Hassan Mohamad, Hajj-Hassan Hussein, Ghafar-Zadeh Ebrahim International Conference on Microelectronics . 2013

机译：多模态神经微探针集成硅微电极和聚合物微通道
5. A three-dimensional silicon-based microelectrode for neural recording [D] . Wang, Ming-Fang 2007

机译：用于神经记录的三维硅基微电极
6. A Novel Fabrication Technique for Liquid-Tight Microchannels by Combination of a Paraffin Polymer and a Photo-Curable Silicone Elastomer [O] . Katsuo Mogi, Kenshiro Sakata, Yuki Hashimoto, 2016

机译：石蜡聚合物和光固化有机硅弹性体的结合用于液密微通道的新型制造技术
7. Dielectric impedance spectroscopy of polymer-coated microelectrodes for adsorption monitoring of proteins within polymer microchannels [O] . Kechadi, Mohammed, Chaal, Lila, Tribollet, Bernard, 2015

机译：聚合物涂层微电极的介电阻抗谱，用于监测聚合物微通道内蛋白质的吸附

Multi-modal neural microprobe integrating silicon microelectrodes and polymeric microchannels

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