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首页> 外文会议>International Conference on Biomedical Engineering >Investigation of Determinants of Atypical Femoral Fractures Using Multiscale Computational Modeling
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Investigation of Determinants of Atypical Femoral Fractures Using Multiscale Computational Modeling

机译：多尺度计算建模的非典型股骨骨折的决定因素调查

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Atypical femoral fractures (AFF) are predominantly transverse stress fractures from the lateral aspect of the subtrochanteric and diaphyseal region for which long-term bisphosphonate treatment have been suggested an important determinants. However, the physiological loading environment triggering AFFs in typical femoral regions remain largely unexplored. The aim of this study was to test the hypothesis that typical AFFs onset location is associated with high daily cyclic tensile strains. The study was based on body- and organ-level models from a single donor (female, 81- years- old) and motion data recorded from a body-matched volunteer (female, 25 years-old). Models were the donor's lower-limb musculoskeletal model validated against published measurements of the hip reaction force and the finite-element model of the donor's right femur validated against measurements of cortical strains. Motion data including skin marker trajectories and ground reaction forces were recorded from the volunteer during walking, which is the most frequent daily activity. The muscle and hip forces were calculated using the musculoskeletal model and applied to the finite-element model to calculate the cortical tensile and compressive strains in two extreme sections of the femoral diaphysis. The anterior, medial, posterior and lateral femoral aspects were assumed at 0°, 90°, 180°, and 270° respectively. In the sub-trochanteric section the peak tensile strain during stance was 1300-2287 με constantly located laterally (270°-300°) and the peak compressive strain was 1433-2730 με constantly located medially (90°). In the distal diaphysis the peak tensile strain varied from 1714 με to 4171 με located antero-laterally at 300°-330° and the peak compressive strain varied from 1813 με to 4674 με located postero-medially (90°-150°). We conclude that high cyclic tensile strains determine the typical AFFs onset location whereas more research is necessary to understand how different activities and the individual anatomy affect the femur's physiological tensile loads.
机译：非典型的股骨骨折（AFF）主要是从针对长期双膦酸盐治疗已经提出的一个重要的决定因素的转子下和骨干区域的横向方面横向应力性骨折。然而，生理负荷环境触发典型的大腿区域AFFS基本上还未。本研究的目的是测试的假设典型AFFS发病位置与高每日循环拉伸应变相关联。这项研究是基于体佩和器官级别车型从单个供体（女，81- years-岁）从体相匹配的志愿者记录运动数据（女性，25岁）。型号分别为授权人的下肢的肌肉骨骼针对髋反作用力的公布的测量和针对皮质菌株的测量验证授权人的右股骨的有限元模型的模型验证。运动数据包括皮肤标记轨道和地面反作用力从行走时的志愿者，这是最常见的日常活动记录。肌肉和髋关节力使用肌骨模型计算并施加到有限元模型来计算在股骨干的两种极端部皮质的拉伸和压缩应变。前，分别假定内侧，后侧和股骨外侧方面，在0°，90°，180°，和270°。在副粗隆部站立期间的峰值拉伸应变为1300至2287年με不断位于横向（270°-300°）和峰值压缩应变是1433年至2730年με不断位于内侧（90°）。在远侧骨干峰值拉伸应变从1714με变化到4171με位于前 - 横向在300℃-330°和峰值压缩应变从1813με变化到4674με位于后 - 内侧（90°-150°）。我们的结论是高循环拉力应变确定典型的AFFS发病位置，而更多的研究是必要了解不同的活动和个体解剖如何影响股骨的生理拉伸载荷。

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