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Understanding of Genetic Code Degeneracy and New Way of Classifying of Protein Family: A Mathematical Approach

机译:了解蛋白质家族分类的遗传规范退化和新方法:数学方法

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The genetic code is the set of rules by which information encoded in genetic material (DNA or RNA sequences) is translated into proteins (amino acid sequences) by living cells. The code maps a tri-nucleotide sequence, called codons, into corresponding amino acids. Since there are 20 amino acids and 64 possible tri-nucleotide sequences, more than one among these 64 triplets can code for a single amino acid which incorporates the problem of degeneracy. This manuscript explains the underlying logic of degeneracy of genetic code based on a mathematical point of view using a parameter named "Impression". Classification of protein family is also a long standing problem in the field of Bio-chemistry and Genomics. Proteins belonging to a particular class have some similar bio-chemical properties which are of utmost importance for new drug design. Using the same parameter "Impression" and using graph theoretic properties we have also devised a new way of classifying a protein family.
机译:遗传密码是一组规则,通过将遗传物质(DNA或RNA序列)编码的信息通过活细胞转化为蛋白质(氨基酸序列)。该代码将三核苷酸序列,称为密码子映射到相应的氨基酸中。由于存在20个氨基酸和64种可能的三核苷酸序列,因此这64个三联体中的多于一个可以为单个氨基酸编码,该氨基酸包含退化问题。此稿件基于使用名为“印象”的参数的数学观点来解释遗传代码的退化性的基础逻辑。蛋白质家族的分类也是生物化学和基因组学领域的长期问题。属于特定阶级的蛋白质具有一些类似的生物化学性质,对于新的药物设计至关重要。使用相同的参数“印象”并使用图形理论属性,我们还规定了分类蛋白质家庭的新方法。

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