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An optical method for rapid screening of blood-borne pathogens

机译：一种快速筛查血型病原体的光学方法

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In clinical laboratory work, blood samples are the most common body material used in daily diagnostic tasks. Donated blood needs to be screened for blood-borne diseases before it can be used. This procedure currently takes about twelve hours of laboratory work, and that is acceptable in the case of blood donations. However, the same verification needs to be done in the case of organ transplantations where a 12-hour wait is way too long. Utilizing the currently most sensitive label-free biosensor technology-surface plasmon resonance (SPR)-with a CCD imaging approach allows the construction of a device capable of fast and sensitive detection of blood-borne pathogens. In this paper, a prototype of such an SPR imaging device is presented. Some of the considerations that allow reaching the needed sensitivity and the prototype measurement results are described as well. The completed system was tested with two materials of different optical density, PBS (phosphate buffered saline) and water, at 20degC and 40degC (near-room and near-body temperatures).
机译：在临床实验室工作中，血液样本是日常诊断任务中最常见的身体材料。在使用之前需要筛选血液传播疾病的捐赠的血液。此程序目前需要大约12个小时的实验室工作，并且在献血的情况下可以接受。然而，在器官移植的情况下，需要进行相同的验证，其中12小时等待太长。利用目前最敏感的无标签的生物传感器技术表面等离子体谐振（SPR） - 用于CCD成像方法，允许构建能够快速敏感血型病原体的装置。在本文中，提出了这种SPR成像装置的原型。允许达到所需灵敏度和原型测量结果的一些考虑因素也被描述。用两种不同光密度，PBS（磷酸盐缓冲盐水）和水，在20DEGC和40DEGC（近室和近体温度）中测试完成的系统。

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