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Image-based detection of Corpus Callosum variability for more accurate discrimination between dyslexic and normal brains

机译：基于图像的Corpus Callosum变异性检测，可更准确地识别阅读困难的大脑与正常的大脑

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Dyslexia severely impairs learning abilities of children, so that improved diagnostic methods are needed. Neuropathological studies have revealed an abnormal anatomy of the Corpus Callosum (CC) in dyslexic brains. We propose a new approach to quantitative analysis of three-dimensional (3D) magnetic resonance images (MRI) of the brain that ensures a more accurate quantification of anatomical differences between the CC of dyslexic and normal subjects. It consists of three main processing steps: (i) segmenting the CC from a given 3D MRI using the learned CC shape and visual appearance; (ii) extracting a centerline of the CC; and (iii) cylindrical mapping of the CC surface for its comparative analysis. Our experiments revealed significant differences (at the 95% confidence level) between 14 normal and 16 dyslexic subjects in four anatomical divisions, i.e. splenium, rostrum, genu and body of their CCs.
机译：阅读障碍严重损害儿童的学习能力，因此需要改进的诊断方法。神经病理学研究已发现阅读困难的大脑the体（CC）的解剖结构异常。我们提出了一种对大脑的三维（3D）磁共振图像（MRI）进行定量分析的新方法，该方法可确保对阅读障碍者和正常受试者的CC之间的解剖差异进行更准确的量化。它包括三个主要的处理步骤：（i）使用学习到的CC形状和视觉外观从给定的3D MRI中分割CC; （ii）提取CC的中心线; （iii）CC曲面的圆柱映射，以进行比较分析。我们的实验揭示了14个正常和16个阅读困难的受试者在四个解剖部位（即其CC的脾脏，讲台，膝和身体）之间存在显着差异（在95％置信水平上）。

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