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首页> 外文会议>World Congress on Medical Physics and Biomedical Engineering >Dosimetric Comparison of 3DCRT, IMRT and VMAT for Spine Radiotherapy based on Secondary Cancer Risk
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Dosimetric Comparison of 3DCRT, IMRT and VMAT for Spine Radiotherapy based on Secondary Cancer Risk

机译：基于二次癌症风险的脊柱放射治疗3DCR，IMRT和VMAT的剂量比较

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This study evaluated the secondary cancer risk after 3D-conformaI radiotherapy (3DCRT), intensity modulated radiotherapy (IMRT) and volumetric modulated arc therapy (VMAT) for spine. Computed tomography image set of a RPC spine anthropomorphic phantom was exported to the Pinnacle3 treatment planning system. Radiation treatment plans for spine were created using the four-field 3DCRT, seven-field IMRT and dual-arc VMAT techniques. The mean and maximum doses, dose-volume histograms and volumes receiving more than 2 Gy and 4 Gy of organs-at-risk (OARs) were calculated and compared. The lifetime risk for secondary cancers was estimated according to NCRP Report 116. Quality Assurances of IMRT and VMAT were performed using the ArcCHECK method with gamma index criteria set to 3%/3mm. For our dosimetric comparisons, planning target volume coverages were found to be 90.5 %, 91.4 % and 95.9 %, for 3DCRT, IMRT and VMAT, respectively. VMAT was found to deliver the lowest maximum dose to esophagus (3.22 Gy), bone (6.48 Gy), heart (1.69 Gy), spinal cord (5.15 Gy) and the whole lung (4.52 Gy). Volumes of esophagus receiving more than 4 Gy were 0% for VMAT, 37.56% for IMRT and up to 43.76% for 3DCRT. The estimated risk for secondary cancer in the respective OAR is considerably lower in VMAT compared to other techniques. Results of maximum doses and volumes of OARs suggest that the risk of secondary cancer induction for spine in VMAT is lower than IMRT and 3DCRT, whereas VMAT has the best target coverage.
机译：本研究评估了3D-ConformaI放射治疗（3DCRT），强度调制放疗（IMRT）和体积调制弧治疗（VMAT）的二次癌症风险。计算机断层摄影图像集的RPC脊柱拟人幽灵般的幻影出口到Pinnacle3治疗计划系统。使用四场3DCRT，七场IMRT和双弧VMAT技术创建脊柱的辐射处理计划。计算和比较超过2GY和4 GY的均值和最大剂量，剂量直方图和体积，并进行比较。根据NCRP报告116估计二次癌症的寿命风险。使用伽马索引标准的ArcCheck方法进行IMRT和VMAT的质量保证，设置为3％/ 3mm。对于我们的描述，分别发现计划目标卷覆盖率分别为3DCRT，IMRT和VMAT的90.5％，91.4％和95.9％。发现VMAT为食道（3.22GY），骨骼（6.48GY），心脏（1.69GY），脊髓（5.15Gy）和整个肺（4.52Gy）提供最低剂量。 VMAT接收超过4 GY的食道卷为0％，37.56％，3DCRT高达43.76％。与其他技术相比，各个OAR中的继发性癌症的估计风险相比，VMAT的巨大风险相比大幅降低。桨的最大剂量和体积的结果表明，VMAT中脊柱血管诱导的风险低于IMRT和3DCRT，而VMAT具有最佳的目标覆盖范围。

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