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Tandem mass spectrometry on a miniaturized laser desorption time-of-flight mass spectrometer

机译：小型激光解吸飞行时间质谱仪上的串联质谱

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Tandem mass spectrometry (MS/MS) is a powerful and widely-used technique for identifying the molecular structure of organic constituents of a complex sample. Application of MS/MS to the study of unknown planetary samples on a remote space mission would contribute to our understanding of the origin, evolution, and distribution of extraterrestrial organics in our solar system. Here we report on the realization of MS/MS on a miniaturized laser desorption time-of-flight mass spectrometer (LD-TOF-MS), which is one of the most promising instrument types for future planetary missions. This achievement relies on two critical components: a curved-field reflectron and a pulsed-pin ion gate. These enable use of the complementary post-source decay (PSD) and laser-assisted collision induced dissociation (L-CID) MS/MS methods on diverse measurement targets with only modest investment in instrument resources such as volume and weight. MS/MS spectra of selected molecular targets in various organic standards exhibit excellent agreement when compared with results from a commercial, laboratory-scale TOF instrument, demonstrating the potential of this powerful technique in space and planetary environments.

机译：串联质谱（MS / MS）是一种功能强大且广泛使用的技术，用于鉴定复杂样品中有机成分的分子结构。 MS / MS在远程太空任务中研究未知行星样本的应用将有助于我们了解太阳系中外星有机物的起源，演化和分布。在这里，我们报告在小型激光解吸飞行时间质谱仪（LD-TOF-MS）上实现MS / MS的情况，这是未来行星飞行任务中最有希望的仪器类型之一。该成就取决于两个关键组件：弯曲场反射器和脉冲引脚离子门。这些使互补的源后衰减（PSD）和激光辅助碰撞诱导解离（L-CID）MS / MS方法可用于多种测量目标，而对仪器资源（如体积和重量）的投入很少。与商用实验室规模TOF仪器的结果相比，各种有机标准物中所选分子靶标的MS / MS光谱显示出极好的一致性，证明了这种强大技术在太空和行星环境中的潜力。

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《IEEE Aerospace Conference》|2016年|1-8|共8页
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Xiang Li; Timothy Cornish; Scott Ecelberger; Stephanie A. Getty; William B. Brinckerhoff;
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laser desorption mass spectrometry (LDMS); laser desorption time-of-flight mass spectrometer (LD-TOF-MS); laser-assisted collision induced dissociation (L-CID); post-source decay (PSD); tandem mass spectrometry (MS/MS);

机译：激光解吸质谱（LDMS）;激光解吸飞行时间质谱仪（LD-TOF-MS）;激光辅助碰撞诱导解离（L-CID）;源后衰减（PSD）;串联质谱（MS） /多发性硬化症）;

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专利

1. In-Source Decay and Pseudo Tandem Mass Spectrometry Fragmentation Processes of Entire High Mass Proteins on a Hybrid Vacuum Matrix-Assisted Laser Desorption Ionization-Quadrupole Ion-Trap Time-of-Flight Mass Spectrometer [J] . Lyna Sellami, Omar Belgacem, Claude Villard, Analytical chemistry . 2012,第12期

机译：混合真空基质辅助激光解吸电离-四极杆离子阱飞行时间质谱仪上全部高质量蛋白质的源内衰减和伪串联质谱裂解过程
2. Direct analysis of sterols by derivatization matrix-assisted laser desorption/ionization time-of-flight mass spectrometry and tandem mass spectrometry [J] . Iyad Hailat, Robert J. Helleur Rapid Communications in Mass Spectrometry: RCM . 2014,第2期

机译：通过衍生化基质辅助激光解吸/电离飞行时间质谱和串联质谱直接分析固醇
3. Characterization of gallotannins from Astronium species by flow injection analysis-electrospray ionization-ion trap-tandem mass spectrometry and matrix-assisted laser desorption/ionization time-of-flight mass spectrometry [J] . Da Silva V.C., Napolitano A., Eletto D., European journal of mass spectrometry . 2011,第4期

机译：流动注射分析-电喷雾电离-离子阱-串联质谱法和基质辅助激光解吸/电离飞行时间质谱法表征天文学中的镓单宁
4. Tandem Mass Spectrometry on a Miniaturized Laser Desorption Time-of-Flight Mass Spectrometer [C] . Xiang Li, Timothy Cornish, Scott Ecelberger, IEEE Aerospace Conference . 2016

机译：在小型激光解吸飞行时间质谱仪上的串联质谱法
5. Part~1. A dual ion source to produce cesium(+) and iodine(-) ions for secondary ion mass spectrometry. Part~2. Investigations of matrix-assisted laser desorption with a reflecting time-of-flight mass spectrometer. [D] . Zhou, Jie. 1994

机译：部分〜1。产生铯（+）和碘（-）离子的双离子源，用于二次离子质谱分析。第二部分用反射飞行时间质谱仪研究基质辅助激光解吸。
6. Multiple Time-of-Flight/Time-of-Flight Events in a Single Laser Shot for Improved Matrix-Assisted Laser Desorption/Ionization Tandem Mass Spectrometry Quantification [O] . Boone M. Prentice, Chad W. Chumbley, Brian C. Hachey, -1

机译：单次激光发射中的多个飞行时间/飞行时间事件用于改进的基质辅助激光解吸/电离串联质谱定量
7. Characterization of gallotannins from Astronium species by flow injection analysis-electrospray ionization-ion trap-tandem mass spectrometry and matrix-assisted laser desorption/ionization time-of-flight mass spectrometry [O] . Viviane Candida da Silva, Assunta Napolitano, Daniela Eletto, 2011

机译：通过流动注射分析 - 电喷雾离子化 - 离子阱 - 串联质谱和基质辅助激光解吸/电离飞行时间质谱对来自天文物种的gall单宁进行表征
8. Tandem Mass Spectrometry on a Miniaturized Laser Desorption Time-of-Flight Mass Spectrometer. [R] . Li, X., Cornish, T., Getty, S. A., 2016

机译：微型激光解吸飞行时间质谱仪的串联质谱分析。

Tandem mass spectrometry on a miniaturized laser desorption time-of-flight mass spectrometer

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