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首页> 外文会议>Congress of the International Pig Veterinary Society >Possibility of oral immunization of piglets against enterotoxigenic strains of Escherichia coli post weaning with colonizing factor F4
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Possibility of oral immunization of piglets against enterotoxigenic strains of Escherichia coli post weaning with colonizing factor F4

机译：用殖民因子F4断奶术后大肠杆菌的肠毒素菌株口服免疫仔猪的可能性

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Strains of enterotoxigenic Escherichia coli (ETEC) are still one of the most frequent causes of post weaning diarrhoea (PWD) in pigs. The disease with variable clinical signs regularly occurs during first two weeks after weaning regardless of age ofweaned piglets. Disease is based on the ability of ETEC to adhere, proliferate and colonize the small intestine and on their production of enterotoxins. Colonization of mucosal surface of the epithelial cells is mediated by colonizing factors (CFs) F4,F5, F6, F41 and F18. However, of the five only F4 and F18 have been detected in the ETEC strains isolated from PWD in the Czech Republic. ETEC strains causing diarrhoea in piglets may produce a heat-labile (LT) enterotoxin or / and two kinds of heat-stable enteroloxins (STa and STb). Immunization against ETEC post weaning is more complicated than in category of sucking piglets. Circulating IgG antibodies of blood have no importance for protection against diarrhoea caused by ETEC. Effective immunizationdepends on activation of gut associated tymphorelicular tissues (GALT). When CFs of nontoxigenic strains of E.coli are used as protective antigens, protection of mucosal surface is avoided by sIgA. Experiments continue on the basis of our successful immunizations with F18. There are differences between strains with F18 and F4 in their immunogenic quality. F4 is a worse immunogen and it is necessary to start vaccination of piglets before weaning. The aim of our experiments was to define the dynamics of antibody litres anti F4 in milk of sows (the first series) and determine on this base day of oral vaccination of piglets with live non-toxigenic strain of E. coli with F4 (the second series).
机译：肠毒素大肠杆菌（ETEC）的菌株仍然是猪中断奶后腹泻（PWD）最常见的原因之一。无论何时服从年龄仔猪，在断奶后的前两周内，疾病都会经常发生。疾病是基于ETEC坚持的能力，增殖和殖民，小肠以及它们的肠毒素的产生。上皮细胞的粘膜表面的定植是通过定植因子（CFS）F4，F5，F6，F41和F18介导的。然而，在从捷克共和国的PWD分离的ETEC菌株中检测到五个仅F4和F18。导致仔猪腹泻的ETEC菌株可以产生热不稳定（LT）肠毒素或/和两种热稳定的肠溶藻（STA和STB）。对ETEC后断奶的免疫比吸吮仔猪在类别中更复杂。循环IgG血液的抗体对ETEC引起的腹泻无重视。肠道相关Tymhoricular组织（GALT）活化的有效免疫依赖性。当E.COLI的非氧基菌株CFS用作保护性抗原时，SIGA避免了粘膜表面的保护。实验在我们的成功免疫与F18继续进行。在免疫原性质量下具有F18和F4的菌株之间存在差异。 F4是更差的免疫原性，有必要在断奶前开始仔猪接种疫苗。我们的实验的目的是定义母猪牛奶（第一个系列）抗体的抗F4的动态，并确定仔猪口服疫苗接种的本地日，具有F4的大肠杆菌的活性非胃肠菌株（第二个系列）。

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