Animal Models of Cancer in the National Toxicology Program

机译：国家毒理学计划中癌症的动物模型

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The National Toxicology Program (NTP) was established in 1978 as a Department of Health and Human Services (DHHS) cooperative effort to develop the scientific information necessary to protect the health of the American public from exposure to hazardous environmental agents. Cancer is a major cause of debilitation and death in humans and animals and identifying potential human carcinogens in rodent bioassays has been a major focus of the NTP. Animal and human cancers are fundamentally similar and frequently share morphological, biological, and molecular biological features. Animal models are revealing the complexities of carcinogenesis and leading to prevention and cures. This presentation will cover the comparative pathology, molecular biology, andhuman relevance of chemically induced liver, intestinal, and vascular tumors in rodents from NTP studies, as well as the utility of genetically modified mice in screening for carcinogens.

机译：国家毒理学计划（NTP）成立于1978年，成为卫生和人类服务部（DHHS）合作努力，开发保护美国公众免于暴露于危险环境代理的科学信息。癌症是人类和动物的衰弱和死亡的主要原因，并鉴定啮齿动物生物测定中的潜在人致癌物质是NTP的主要焦点。动物和人类癌症从根本上类似，经常均有形态学，生物学和分子生物学特征。动物模型揭示了致癌物的复杂性，导致预防和治愈。该介绍将涵盖来自NTP研究的啮齿动物中的化学诱导肝，肠道和血管肿瘤的比较病理，分子生物学，和血管瘤的相关性，以及遗传修饰小鼠在筛选致癌物质中的效用。

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《Annual Meeting of the American Society for Veterinary Clinical Pathology》|2011年||共4页
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David E. Malarkey;
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3. Supplement to the Carcinogenic Potency Database (CPDB): results of animal bioassays published in the general literature through 1997 and by the National Toxicology Program in 1997-1998. [J] . Gold LS, Manley NB, Slone TH, Toxicological sciences: An official journal of the Society of Toxicology . 2005,第2期

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4. Animal Models of Cancer in the National Toxicology Program [C] . David E. Malarkey Annual Meeting of the American Society for Veterinary Clinical Pathology . 2011

机译：国家毒理学计划中癌症的动物模型
5. The development of Drosophila as an animal model for studying the behavioral genetics of lead toxicology. [D] . Wilson, Diane T. 2004

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机译：致癌性数据库：分析了一般文献中以及美国国家癌症研究所/国家毒理学计划发布的4000种慢性动物癌症实验。
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机译：世界贸易中心潜在关注的化学品和选定的其他化学品。国家毒理学计划和国际癌症研究机构的癌症分类摘要

Animal Models of Cancer in the National Toxicology Program

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